Department of Ophthalmology, Osaka University Graduate School of Medicine, Room E7, 2-2 Yamadaoka, Suita, Osaka, 565-0871, Japan,
Jpn J Ophthalmol. 2013 Sep;57(5):440-6. doi: 10.1007/s10384-013-0251-y. Epub 2013 Jun 6.
To evaluate the preliminary long-term efficacy of diquafosol ophthalmic solution for aqueous-deficient dry eye.
Fifteen patients with mild-to-moderate aqueous-deficient dry eye were enrolled. After a washout period, the patients were treated with 3 % diquafosol ophthalmic solution for 6 months. We assessed 12 subjective dry eye symptoms, corneal and conjunctival staining with fluorescein, tear film break-up time (BUT), lower tear meniscus height measured with anterior-segment optical coherence tomography, Schirmer's testing, and adverse reactions at baseline and 1, 3, and 6 months after the start of treatment.
Treatment with diquafosol ophthalmic solution significantly improved dry eye symptoms, corneal staining, BUT, and tear meniscus height at 1 month and maintained the effectiveness for 6 months. Conjunctival staining significantly improved 3 and 6 months after treatment. No significant adverse reactions developed.
Prolonged use of diquafosol ophthalmic solution for 6 months produced significant improvement both subjectively (dry eye symptom score) and objectively (ocular staining score and tear function tests) for aqueous-deficient dry eye.
评估双氯非腙滴眼液治疗水样液缺乏性干眼症的初步长期疗效。
纳入 15 例轻至中度水样液缺乏性干眼症患者。在洗脱期后，患者使用 3%双氯非腙滴眼液治疗 6 个月。我们评估了 12 项主观干眼症状、角膜和结膜荧光素染色、泪膜破裂时间（BUT）、前节光学相干断层扫描测量的下泪膜高度、泪液分泌试验和不良反应，在基线和治疗开始后 1、3 和 6 个月进行评估。
双氯非腙滴眼液治疗可显著改善干眼症状、角膜染色、BUT 和泪膜高度，在 1 个月时有效，6 个月时仍有效。结膜染色在治疗 3 个月和 6 个月后显著改善。未出现明显不良反应。
双氯非腙滴眼液长期使用 6 个月可显著改善水样液缺乏性干眼症的主观症状（干眼症状评分）和客观指标（眼部染色评分和泪液功能检查）。
