Department of Ophthalmology, University of Tsukuba, Ibaraki, Japan.
J Cataract Refract Surg. 2010 Nov;36(11):1867-73. doi: 10.1016/j.jcrs.2010.05.024.
To evaluate the repeatability and reproducibility of central corneal thickness (CCT), anterior chamber depth (ACD), and anterior chamber width (ACW) measurements using 3-dimensional (3-D) corneal and anterior segment optical coherence tomography (CAS-OCT) and 2-dimensional (2-D) anterior segment OCT (AS-OCT).
Department of Ophthalmology, Institute of Clinical Medicine, University of Tsukuba, Ibaraki, Japan.
Nonrandomized clinical trial.
The CCT, ACD, and ACW were measured in normal eyes using a prototype 3-D swept-source CAS-OCT device and a 2-D time-domain AS-OCT device (Visante). The coefficient of repeatability and reproducibility and the intraclass correlation coefficient (ICC) were calculated to evaluate the repeatability and reproducibility of the measurements.
Eighty-five eyes (85 subjects) were evaluated. The mean CCT measurement was 557.5 μm ± 40.5 (SD) with CAS-OCT and 556.4 ± 39.4 μm with AS-OCT; the mean ACD measurement, 3.13 ± 0.40 mm and 3.16 ± 0.39 mm, respectively; and the mean ACW, 11.80 ± 0.47 mm and 11.79 ± 0.49 mm, respectively. There was no statistically significant difference in CCT or ACW measurements between the 2 devices (P>.05, Wilcoxon signed rank test). Although the ACD measurements were significantly different (P<.0001), the difference was small (0.03 mm). Significant linear correlations were found between the measurements of the 2 devices (P<.0001). The ICC was greater than 0.99 for CAS-OCT and greater than 0.96 for AS-OCT.
Corneal and anterior segment OCT and AS-OCT provided comparable and well-correlated anterior ocular biometric measurements, with sufficient repeatability and reproducibility.
评估三维（3D）角膜和眼前段光学相干断层扫描（CAS-OCT）和二维（2D）眼前段 OCT（AS-OCT）测量中央角膜厚度（CCT）、前房深度（ACD）和前房宽度（ACW）的重复性和再现性。
日本筑波大学临床医学院眼科。
非随机临床试验。
使用原型 3D 扫频源 CAS-OCT 设备和 2D 时域 AS-OCT 设备（Visante）对正常眼进行 CCT、ACD 和 ACW 测量。计算重复性和再现性系数和组内相关系数（ICC），以评估测量的重复性和再现性。
评估了 85 只眼（85 例）。使用 CAS-OCT 测量的平均 CCT 为 557.5μm±40.5（SD），使用 AS-OCT 测量的平均 CCT 为 556.4μm±39.4μm；平均 ACD 测量值分别为 3.13±0.40mm 和 3.16±0.39mm；平均 ACW 测量值分别为 11.80±0.47mm 和 11.79±0.49mm。两种设备之间的 CCT 或 ACW 测量值无统计学差异（P>.05，Wilcoxon 符号秩检验）。尽管 ACD 测量值差异显著（P<.0001），但差异较小（0.03mm）。两种设备之间存在显著的线性相关性（P<.0001）。CAS-OCT 的 ICC 大于 0.99，AS-OCT 的 ICC 大于 0.96。
角膜和眼前段 OCT 和 AS-OCT 提供了可比较且相关性良好的眼前部生物测量值，具有足够的重复性和再现性。
