Department of Cell Biology, Yale School of Medicine, New Haven, CT, USA.
EMBO Mol Med. 2013 Jul;5(7):973-83. doi: 10.1002/emmm.201100671. Epub 2013 Jun 6.
Lipid droplets (LDs) are dynamic, cytosolic lipid-storage organelles found in nearly all cell types. Too many or too few LDs during excess or deficient fat storage lead to many different human diseases. Recent insights into LD biology and LD protein functions shed new light on mechanisms underlying those metabolic pathologies. These findings will likely provide opportunities for treatment of diseases associated with too much or too little fat.
脂滴（LDs）是存在于几乎所有细胞类型中的动态、胞质脂质储存细胞器。在脂肪储存过多或不足时，LD 过多或过少会导致许多不同的人类疾病。最近对 LD 生物学和 LD 蛋白功能的深入了解为这些代谢病理学的潜在机制提供了新的线索。这些发现可能为治疗与脂肪过多或过少相关的疾病提供机会。
