脂滴作为骨骼肌细胞命运的决定因素。
Lipid droplets as cell fate determinants in skeletal muscle.
作者信息
Chen Jingjuan, Markworth James F, Ferreira Christina, Zhang Chi, Kuang Shihuan
机构信息
Department of Animal Sciences, Purdue University, West Lafayette, IN 47907, USA; Department of Orthopaedic Surgery, Duke University, Durham, NC 27710, USA.
Department of Animal Sciences, Purdue University, West Lafayette, IN 47907, USA.
出版信息
Trends Endocrinol Metab. 2024 Nov 28. doi: 10.1016/j.tem.2024.10.006.
Lipid droplets (LDs) are dynamic organelles that communicate with other cellular components to orchestrate energetic homeostasis and signal transduction. In skeletal muscle, the presence and importance of LDs have been widely studied in myofibers of both rodents and humans under physiological conditions and in metabolic disorders. However, the role of LDs in myogenic stem cells has only recently begun to be unveiled. In this review we briefly summarize the process of LD biogenesis and degradation in the most prevalent model. We then review recent knowledge on LDs in skeletal muscle and muscle stem cells. We further introduce advanced methodologies for LD imaging and mass spectrometry that have propelled our understanding of the dynamics and heterogeneity of LDs.
脂滴（LDs）是动态细胞器，与其他细胞成分相互作用以协调能量稳态和信号转导。在骨骼肌中，脂滴的存在及其重要性已在生理条件下以及代谢紊乱状态下的啮齿动物和人类肌纤维中得到广泛研究。然而，脂滴在成肌干细胞中的作用直到最近才开始被揭示。在这篇综述中，我们简要总结了最普遍模型中脂滴生物发生和降解的过程。然后我们回顾了关于骨骼肌和肌肉干细胞中脂滴的最新知识。我们还介绍了用于脂滴成像和质谱分析的先进方法，这些方法推动了我们对脂滴动力学和异质性的理解。
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