Department of Orthopedics, Shanghai Key Laboratory of Orthopedic Implants, Shanghai Ninth People's Hospital, Shanghai Jiaotong University School of Medicine, Shanghai, China.
J Clin Microbiol. 2013 Aug;51(8):2742-6. doi: 10.1128/JCM.00657-13. Epub 2013 Jun 5.
We performed a meta-analysis to evaluate use of PCR assays for diagnosis of prosthetic joint infection (PJI). The pooled sensitivity and specificity were 0.86 (95% confidence interval [CI], 0.77 to 0.92) and 0.91 (CI, 0.81 to 0.96), respectively. Subgroup analyses showed that use of tissue samples may improve sensitivity, and quantitative PCR and sonication of prostheses fluid may improve specificity. The results showed that PCR is reliable and accurate for detection of PJI.
我们进行了荟萃分析，以评估聚合酶链反应（PCR）检测在诊断人工关节感染（PJI）中的应用。汇总的敏感性和特异性分别为 0.86（95%置信区间 [CI]，0.77 至 0.92）和 0.91（CI，0.81 至 0.96）。亚组分析表明，使用组织样本可能会提高敏感性，而定量 PCR 和假体液的超声处理可能会提高特异性。结果表明，PCR 是一种可靠且准确的检测 PJI 的方法。
