Wolfe Preston N, Campfield Brian D, Crist Brett D, Keeney James A, Smith Matthew J, Cook James L, Stoker Aaron M
University of Missouri, Thompson Laboratory for Regenerative Orthopaedics, Missouri Orthopaedic Institute, 1100 Virginia Ave., Columbia, MO, 65212, USA.
University of Missouri, Department of Orthopaedic Surgery, Missouri Orthopaedic Institute, 1100 Virginia Ave., Columbia, MO, 65212, USA.
J Orthop. 2021 Aug 25;27:56-62. doi: 10.1016/j.jor.2021.08.012. eCollection 2021 Sep-Oct.
To provide an initial characterization of relevant bacterial DNA profiles for patients undergoing closed-fracture fixation or total joint arthroplasties.
Swabs were collected and analyzed using Polymerase Chain Reaction from adult patients undergoing closed-fracture fixation or total shoulder, knee, or hip arthroplasties.
Bacterial DNA profiles varied across the different orthopaedic patient populations, and produced uncharacteristic profile shifts with direct relevance to each clinical infection.
Findings provide a foundational dataset regarding bacterial colonization of relevant anatomic sites that can act as sources of surgical site infections for patients.
对接受闭合性骨折固定术或全关节置换术的患者相关细菌DNA图谱进行初步表征。
对接受闭合性骨折固定术或全肩关节、膝关节或髋关节置换术的成年患者采集拭子,并使用聚合酶链反应进行分析。
不同骨科患者群体的细菌DNA图谱各不相同,并产生了与每种临床感染直接相关的非典型图谱变化。
研究结果提供了一个关于相关解剖部位细菌定植的基础数据集,这些部位可能是患者手术部位感染的来源。