repulsive guidance molecules (RGMs) 和 neogenin 在骨形态发生蛋白 (BMP) 信号通路中的作用。
Repulsive guidance molecules (RGMs) and neogenin in bone morphogenetic protein (BMP) signaling.
机构信息
Department of Molecular Biology and Genetics, Cornell University, Ithaca, New York.
出版信息
Mol Reprod Dev. 2013 Sep;80(9):700-17. doi: 10.1002/mrd.22199. Epub 2013 Jul 19.
Abstract
Bone morphogenetic proteins (BMPs) belong to the transforming growth factor-beta (TGFβ) superfamily. BMPs mediate a highly conserved signal transduction cascade through the type-I and type-II serine/threonine kinase receptors and intracellular Smad proteins, which regulate multiple developmental and homeostatic processes. Mutations in this pathway can cause various diseases in humans, such as skeletal disorders, cardiovascular diseases, and various cancers. Multiple levels of regulation, including extracellular regulation, help to ensure proper spatiotemporal control of BMP signaling in the right cellular context. The family of repulsive guidance molecules (RGMs) and the type-I transmembrane protein neogenin, a paralog of DCC (Deleted in Colorectal Cancer), have been implicated in modulating the BMP pathway. In this review, we discuss the properties and functions of RGM proteins and neogenin, focusing on their roles in the modulation of BMP signal transduction.
摘要
骨形态发生蛋白（BMPs）属于转化生长因子-β（TGFβ）超家族。BMP 通过 I 型和 II 型丝氨酸/苏氨酸激酶受体和细胞内 Smad 蛋白介导高度保守的信号转导级联反应，调节多种发育和稳态过程。该途径中的突变可导致人类多种疾病，如骨骼疾病、心血管疾病和各种癌症。包括细胞外调节在内的多个调节层次有助于确保在正确的细胞环境中对 BMP 信号进行适当的时空控制。排斥性导向分子（RGM）家族和 I 型跨膜蛋白 neogenin（结直肠癌缺失基因（DCC）的同源物）已被牵连到调节 BMP 途径中。在这篇综述中，我们讨论了 RGM 蛋白和 neogenin 的特性和功能，重点介绍了它们在调节 BMP 信号转导中的作用。
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