Cancer Biology and Genetics Program, Memorial Sloan-Kettering Cancer Center, New York, New York 10065, USA.
Nat Rev Mol Cell Biol. 2012 Oct;13(10):616-30. doi: 10.1038/nrm3434. Epub 2012 Sep 20.
The basic elements of the transforming growth factor-β (TGFβ) pathway were revealed more than a decade ago. Since then, the concept of how the TGFβ signal travels from the membrane to the nucleus has been enriched with additional findings, and its multifunctional nature and medical relevance have relentlessly come to light. However, an old mystery has endured: how does the context determine the cellular response to TGFβ? Solving this question is key to understanding TGFβ biology and its many malfunctions. Recent progress is pointing at answers.
转化生长因子-β（TGFβ）通路的基本要素在十多年前就被揭示出来了。从那时起，TGFβ 信号从细胞膜传递到细胞核的概念随着更多的发现而得到了丰富，其多功能性和医学相关性也不断被揭示出来。然而，一个古老的谜团仍然存在：上下文如何决定细胞对 TGFβ 的反应？解决这个问题是理解 TGFβ 生物学及其许多功能障碍的关键。最近的进展正在指向答案。
