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本文引用的文献

1
Pinpointing beta adrenergic receptor in ageing pathophysiology: victim or executioner? Evidence from crime scenes.从犯罪现场证据看，β肾上腺素能受体在衰老病理生理学中究竟是受害者还是刽子手？
Immun Ageing. 2013 Mar 15;10(1):10. doi: 10.1186/1742-4933-10-10.
2
Decreased parathyroid hormone levels despite persistent hypocalcemia in patients with kidney failure recovering from septic shock.感染性休克恢复过程中的肾衰竭患者，尽管持续存在低钙血症，但甲状旁腺激素水平却降低。
Endocr Metab Immune Disord Drug Targets. 2013 Jun;13(2):135-42. doi: 10.2174/1871530311313020001.
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Effects of Aging on Inflammation and Hemostasis through the Continuum of Critical Illness.衰老对危重病连续体中炎症和止血的影响。
Aging Dis. 2011 Dec;2(6):501-11. Epub 2011 Dec 2.
4
The effects of age on inflammatory and coagulation-fibrinolysis response in patients hospitalized for pneumonia.肺炎住院患者炎症和凝血-纤溶反应的年龄影响。
PLoS One. 2010 Nov 4;5(11):e13852. doi: 10.1371/journal.pone.0013852.
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Aging of the innate immune system.固有免疫系统的衰老。
Curr Opin Immunol. 2010 Aug;22(4):507-13. doi: 10.1016/j.coi.2010.05.003.
6
beta2-Adrenergic receptor gene polymorphism is associated with mortality in septic shock.β2-肾上腺素能受体基因多态性与脓毒性休克患者死亡率相关。
Am J Respir Crit Care Med. 2010 Jan 15;181(2):143-9. doi: 10.1164/rccm.200903-0332OC. Epub 2009 Oct 22.
7
T-cell immunosenescence: lessons learned from mouse models of aging.T细胞免疫衰老：从衰老小鼠模型中获得的经验教训。
Trends Immunol. 2009 Jul;30(7):301-5. doi: 10.1016/j.it.2009.04.007. Epub 2009 Jun 21.
8
Human innate immunosenescence: causes and consequences for immunity in old age.人类先天性免疫衰老：老年免疫的原因及后果
Trends Immunol. 2009 Jul;30(7):325-33. doi: 10.1016/j.it.2009.05.004. Epub 2009 Jun 21.
9
Effects of aging on T cell function.衰老对T细胞功能的影响。
Curr Opin Immunol. 2009 Aug;21(4):414-7. doi: 10.1016/j.coi.2009.05.009. Epub 2009 Jun 6.
10
CD4+ T cells and immunosenescence--a mini-review.CD4 + T细胞与免疫衰老——一篇综述短文
Gerontology. 2009;55(5):491-5. doi: 10.1159/000214842. Epub 2009 Apr 23.

老年人脓毒性休克：一项前瞻性队列研究。

Septic shock in older people: a prospective cohort study.

机构信息

Emergency Medicine Department, University of São Paulo, São Paulo, Brazil.

出版信息

Immun Ageing. 2013 Jun 6;10(1):21. doi: 10.1186/1742-4933-10-21.

DOI:10.1186/1742-4933-10-21
PMID:23742671
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC3685530/
Abstract

BACKGROUND

Septic shock is the first cause of death in Intensive Care Units. Despite experimental data showing increased inflammatory response of aged animals following infection, the current accepted hypothesis claims that aged patients are immunocompromised, when compared to young individuals.

RESULTS

Here, we describe a prospective cohort study designed to analyze the immune profile of this population.

CONCLUSION

Older people are as immunocompetent as the young individual, regarding the cytokines, chemokines and growth factors response to devastating infection.

摘要

背景

感染性休克是重症监护病房死亡的首要原因。尽管实验数据表明，感染后老年动物的炎症反应增强，但目前公认的假说认为，与年轻个体相比，老年患者的免疫功能受损。

结果

在这里，我们描述了一项旨在分析该人群免疫特征的前瞻性队列研究。

结论

老年人在细胞因子、趋化因子和生长因子对破坏性感染的反应方面与年轻个体一样具有免疫能力。