The Clinical Research, Investigation, and Systems Modeling of Acute Illness (CRISMA) Laboratory, Department of Critical Care Medicine, University of Pittsburgh, Pittsburgh, PA, USA.
Aging Dis. 2011 Dec;2(6):501-11. Epub 2011 Dec 2.
Older age has long been associated with altered inflammation and hemostasis regulation. Emerging evidence suggests that age-related differences in inflammation and hemostasis abnormalities may play a role in the development of and long-term outcomes after critical illness. A better understanding of underlying mechanisms may provide new possibilities for therapeutic interventions. In this review, we will examine how age-related differences in inflammatory and coagulation responses are affected through the continuum of healthy state, before infection occurs, to severe sepsis and recovery.
老年一直与炎症和止血调节的改变有关。新出现的证据表明，与年龄相关的炎症和止血异常差异可能在危重病的发生和长期结局中起作用。更好地了解潜在的机制可能为治疗干预提供新的可能性。在这篇综述中，我们将研究炎症和凝血反应的年龄相关差异如何通过健康状态的连续体受到影响，从感染前到严重败血症和恢复。
