Laboratory Service, Dr. Felipe A. Fossati Balcarce Hospital, Balcarce, Buenos Aires, Argentina.
Life Sci. 2013 Jul 30;93(2-3):64-8. doi: 10.1016/j.lfs.2013.05.021. Epub 2013 Jun 3.
This study aims to evaluate the relationship between the amount of physical activity and different traditional and novel cardiometabolic risk factors, as well as atheroprotective agents, in male children and adolescents.
Cross-sectional study. A total of 337 male children and adolescents aged 7-14 years old from the rural city of Balcarce, Buenos Aires, Argentina were studied.
The main finding of the present study was that, in male children and adolescents, physical activity was inversely associated with lipoprotein-associated phospholipase A2 (Lp-PLA2) activity (r=-0.39, p<0.001) and with cholesteryl ester transfer protein activity (r=-0.23, p<0.05) apart from other proatherogenic agents after adjusting for age and BMI. Strikingly, among the parameters evaluated, overweight, hyperglycemia and Lp-PLA2 activity resulted to be independently related to physical activity as shown by stepwise regression analysis.
The strong negative association between exercise and Lp-PLA2 activity and the fact that the latter resulted to be the unique continuous variable that persisted associated with physical activity would add an additional benefit of exercise in early prevention of vascular inflammation and atherogenesis.
本研究旨在评估男性儿童和青少年的体力活动量与不同传统和新型心血管代谢风险因素以及动脉保护因子之间的关系。
横断面研究。共纳入 337 名年龄在 7-14 岁的来自阿根廷布宜诺斯艾利斯省巴尔卡塞农村城市的男性儿童和青少年。
本研究的主要发现是，在男性儿童和青少年中，体力活动与脂蛋白相关磷脂酶 A2（Lp-PLA2）活性（r=-0.39，p<0.001）和胆固醇酯转移蛋白活性（r=-0.23，p<0.05）呈负相关，且这种相关性独立于年龄和 BMI 之外。值得注意的是，在评估的参数中，超重、高血糖和 Lp-PLA2 活性通过逐步回归分析显示与体力活动独立相关。
运动与 Lp-PLA2 活性之间的强烈负相关，以及后者是唯一与体力活动持续相关的连续变量，这将为运动在早期预防血管炎症和动脉粥样硬化形成方面提供额外的益处。
