Center for Tuberculosis Research, Johns Hopkins University School of Medicine, Baltimore, MD, USA.
Int J Tuberc Lung Dis. 2013 Jul;17(7):856-65. doi: 10.5588/ijtld.13.0059.
As active screening strategies for tuberculosis (TB) continue to rise globally, it has become increasingly important to consider the methodological challenges in designing and implementing these strategies. The key challenges associated with TB screening can be summarized in terms of four continua or spectra, namely those of 1) TB disease and diagnostic yield, 2) TB risk and resource availability, 3) TB screening strategies, and 4) outcomes and impact measurements of screening programs. In this review, we provide a discussion of these challenges to help guide development of TB screening strategies that will be effective in a given epidemiological setting.
随着全球范围内针对结核病（TB）的主动筛查策略不断增加，考虑在设计和实施这些策略时所面临的方法学挑战变得愈发重要。TB 筛查相关的主要挑战可概括为四个连续体或光谱，即 1）TB 疾病和诊断收益，2）TB 风险和资源可用性，3）TB 筛查策略，以及 4）筛查计划的结果和影响衡量。在本文中，我们对这些挑战进行了讨论，以帮助指导在特定流行病学环境下制定有效的 TB 筛查策略。
