From the Departments of *Infectious Diseases and †Clinical Microbiology, Aalborg University Hospital, Aalborg; and ‡Department of Clinical Microbiology, Slagelse Hospital, Slagelse, Denmark.
Pediatr Infect Dis J. 2013 Nov;32(11):1194-8. doi: 10.1097/INF.0b013e31829f0aff.
There is only sparse information about the clinical impact of Campylobacter concisus infections in children.
A study was performed during a 2-year period to determine the clinical manifestations in C. concisus-positive children with gastroenteritis. A case patient was defined as a child or teenager (<18 years) with a C. concisus-positive stool sample during the study period. Clinical data were obtained with use of a questionnaire study supplemented with the patients' medical records. The clinical manifestations in these patients were compared with those of patients with Campylobacter jejuni/coli infection.
Two thousand three hundred seventy-two diarrheic stool samples from 1867 children were cultured for pathogenic enteric bacteria during the study period, and 85 and 109 children with C. concisus and C. jejuni/coli, respectively, were identified. Comparison of the acute clinical manifestations in 44 C. concisus patients with those in 64 C. jejuni/coli patients showed a significantly lower prevalence of fever, chills and blood in stools in the former. However, half of C. concisus patients compared with one-fourth of C. jejuni/coli patients had prolonged diarrhea for more than 2 weeks and two-thirds of all children with C. concisus reported loose stools after 6-month follow-up.
C. concisus infection in children seems to have a milder course of acute gastroenteritis compared with C. jejuni/coli infection but is associated with more prolonged diarrhea. Children with C. concisus have the same degree of late gastrointestinal complaints as children diagnosed with C. jejuni/coli infection.
关于空肠弯曲菌感染对儿童的临床影响，仅有少量信息。
本研究在 2 年期间进行，以确定空肠弯曲菌阳性儿童肠胃炎的临床表现。病例定义为在研究期间粪便空肠弯曲菌阳性的儿童或青少年(<18 岁)。采用问卷调查和患者病历补充的方法获取临床数据。将这些患者的临床表现与弯曲菌属空肠亚种/大肠埃希菌感染患者的临床表现进行比较。
在研究期间，对 1867 名儿童的 2372 份腹泻粪便样本进行了致病性肠道细菌培养，分别鉴定出 85 名和 109 名空肠弯曲菌和弯曲菌属空肠亚种/大肠埃希菌感染的儿童。44 例空肠弯曲菌患者的急性临床表现与 64 例弯曲菌属空肠亚种/大肠埃希菌感染患者的临床表现进行比较，前者发热、寒战和粪便带血的发生率明显较低。然而，一半的空肠弯曲菌患者比四分之一的弯曲菌属空肠亚种/大肠埃希菌患者腹泻持续时间超过 2 周，所有儿童中有三分之二在 6 个月随访后报告大便松散。
与弯曲菌属空肠亚种/大肠埃希菌感染相比，儿童空肠弯曲菌感染似乎急性肠胃炎的病程较轻，但与更持久的腹泻有关。空肠弯曲菌感染的儿童与诊断为弯曲菌属空肠亚种/大肠埃希菌感染的儿童具有相同程度的晚期胃肠道症状。
