Institute of Infectious Diseases, Southwest Hospital, The Third Military Medical University, Chongqing 400038, People's Republic of China.
J Cancer Res Clin Oncol. 2013 Aug;139(8):1417-24. doi: 10.1007/s00432-013-1458-5. Epub 2013 Jun 7.
Glypican-3(GPC3) has been reported as one of the most promising serum markers for hepatocellular carcinoma (HCC), while several studies have conflicting results for the diagnostic accuracy between GPC3 and alpha-fetoprotein (AFP).
Studies that explored the diagnostic value of GPC3 and AFP in HCC were searched in MEDLINE, EMBASE, PUBMED, the Cochrane Library and Chinese biomedical literature database (CBM). Sensitivity, specificity and other measures about the accuracy of serum GPC3 and AFP in the diagnosis of HCC were pooled using random effects models. Summary receiver operating characteristic curve (sROC) analysis was used to summarize the overall test performance.
Ten studies were included in our meta-analysis. The pooled sensitivity for AFP and GPC3 is 51.9% (95% confidence interval (CI) 0.47-0.56) and 59.2% (95% CI 0.55-0.63), respectively, while the pooled specificity for AFP and GPC3 is 94% (95% CI 92.1-95.6%) and 84.8% (95% CI 82-87.3%), respectively. The pooled diagnostic odds ratio (DOR) for AFP and GPC3 were 23.4 (95% CI 10.3-53.2) and 17.99 (95% CI 5.4-60.4), respectively. Area under sROC for both AFP and GPC3 is 0.81 (95% CI 0.77-0.84).
GPC3 is comparable to AFP as a serum marker for the diagnosis of HCC, combination of AFP and GPC3 can elevate the sensitivity of diagnosis.
磷脂酰聚糖-3（GPC3）已被报道为肝细胞癌（HCC）最有前途的血清标志物之一，而几项研究对 GPC3 和甲胎蛋白（AFP）之间的诊断准确性存在相互矛盾的结果。
在 MEDLINE、EMBASE、PUBMED、Cochrane 图书馆和中国生物医学文献数据库（CBM）中搜索了探讨 GPC3 和 AFP 对 HCC 诊断价值的研究。使用随机效应模型汇总血清 GPC3 和 AFP 对 HCC 诊断准确性的灵敏度、特异性和其他指标。汇总受试者工作特征曲线（sROC）分析用于总结整体测试性能。
我们的荟萃分析纳入了 10 项研究。AFP 和 GPC3 的合并灵敏度分别为 51.9%（95%置信区间（CI）0.47-0.56）和 59.2%（95% CI 0.55-0.63），而 AFP 和 GPC3 的合并特异性分别为 94%（95% CI 92.1-95.6%）和 84.8%（95% CI 82-87.3%）。AFP 和 GPC3 的合并诊断比值比（DOR）分别为 23.4（95% CI 10.3-53.2）和 17.99（95% CI 5.4-60.4）。AFP 和 GPC3 的 sROC 曲线下面积分别为 0.81（95% CI 0.77-0.84）。
GPC3 可与 AFP 一样作为 HCC 的血清标志物，联合使用 AFP 和 GPC3 可提高诊断的灵敏度。
