苦参根及一种活性成分的抗溃疡作用。I.
Antiulcer action of Sophora flavescens root and an active constituent. I.
作者信息
Yamahara J, Mochizuki M, Fujimura H, Takaishi Y, Yoshida M, Tomimatsu T, Tamai Y
机构信息
Kyoto Pharmaceutical University, Kyoto, Japan.
出版信息
J Ethnopharmacol. 1990 May;29(2):173-7. doi: 10.1016/0378-8741(90)90053-v.
PMID:2374430
Abstract
The effect of a methanol extract of Sophora flavescens root was examined on gastric ulcers induced in rats by HCl/ethanol in order to substantiate its reputed protective properties. Oral doses of 1 g/kg completely suppressed ulceration. Results suggest that oral administration of 50 mg/kg of vexibinol, a flavanol found in the extract, inhibited ulceration more effectively than spizofurone at 100 mg/kg.
摘要
为证实苦参根甲醇提取物所谓的保护特性，研究了其对盐酸/乙醇诱导的大鼠胃溃疡的影响。口服剂量为1 g/kg时可完全抑制溃疡形成。结果表明，口服50 mg/kg的提取物中所含黄烷醇紫穗槐醇，比100 mg/kg的螺佐呋酮更有效地抑制溃疡形成。
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