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一种分泌型的 PTEN 磷酸酶，它进入细胞以改变信号转导和存活。

A secreted PTEN phosphatase that enters cells to alter signaling and survival.

机构信息

Department of Oncological Sciences, Icahn School of Medicine at Mount Sinai, 1470 Madison Avenue, New York, NY 10029, USA.

出版信息

Science. 2013 Jul 26;341(6144):399-402. doi: 10.1126/science.1234907. Epub 2013 Jun 6.

DOI:10.1126/science.1234907
PMID:23744781
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC3935617/
Abstract

Phosphatase and tensin homolog on chromosome ten (PTEN) is a tumor suppressor and an antagonist of the phosphoinositide-3 kinase (PI3K) pathway. We identified a 576-amino acid translational variant of PTEN, termed PTEN-Long, that arises from an alternative translation start site 519 base pairs upstream of the ATG initiation sequence, adding 173 N-terminal amino acids to the normal PTEN open reading frame. PTEN-Long is a membrane-permeable lipid phosphatase that is secreted from cells and can enter other cells. As an exogenous agent, PTEN-Long antagonized PI3K signaling and induced tumor cell death in vitro and in vivo. By providing a means to restore a functional tumor-suppressor protein to tumor cells, PTEN-Long may have therapeutic uses.

摘要

磷酸酶和张力蛋白同源物第十号染色体（PTEN）是一种肿瘤抑制因子，也是磷酸肌醇-3 激酶（PI3K）途径的拮抗剂。我们鉴定了一种 576 个氨基酸的 PTEN 翻译变体，称为 PTEN-Long，它来源于 ATG 起始序列上游 519 个碱基的替代翻译起始位点，在正常的 PTEN 开放阅读框中添加了 173 个 N 端氨基酸。PTEN-Long 是一种膜通透性脂磷酸酶，可从细胞中分泌出来，并可进入其他细胞。作为一种外源性试剂，PTEN-Long 拮抗了 PI3K 信号通路，并在体外和体内诱导肿瘤细胞死亡。通过提供一种将功能性肿瘤抑制蛋白恢复到肿瘤细胞的方法，PTEN-Long 可能具有治疗用途。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/79be/3935617/0335aaa13429/nihms548914f4.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/79be/3935617/71ded857b36e/nihms548914f1.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/79be/3935617/766f8eff1fad/nihms548914f2.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/79be/3935617/da6173cba1b9/nihms548914f3.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/79be/3935617/0335aaa13429/nihms548914f4.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/79be/3935617/71ded857b36e/nihms548914f1.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/79be/3935617/766f8eff1fad/nihms548914f2.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/79be/3935617/da6173cba1b9/nihms548914f3.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/79be/3935617/0335aaa13429/nihms548914f4.jpg

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2
Pten in stromal fibroblasts suppresses mammary epithelial tumours.基质成纤维细胞中的Pten抑制乳腺上皮肿瘤。
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Activation of the PI3K pathway in cancer through inhibition of PTEN by exchange factor P-REX2a.通过交换因子P-REX2a抑制PTEN激活癌症中的PI3K通路。
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