Department of Otolaryngology-Head and Neck Surgery, Nara Medical University School of Medicine, Nara, Japan.
Otolaryngol Head Neck Surg. 2013 Aug;149(2):342-4. doi: 10.1177/0194599813492654. Epub 2013 Jun 6.
We used polyglycolic acid (PGA) sheets, a reinforcing material, as supporting devices for securing the fascia instead of fibrin glue or Gelfoam in patients with tympanic membrane (TM) perforations. PGA sheets were placed lateral to the fascia graft attached using the underlay grafting technique in 6 patients. In each case, the PGA sheet had been macerated and had merged into the fascia within 1 week of the procedure. At 2 to 3 postoperative weeks, parts of the sheet had become dehydrated and detached from the fascia, revealing a new epithelialized TM underneath. Eventually, the sheet had disappeared, and complete epithelialization had been achieved at 4 to 5 postoperative weeks, resulting in the successful closure of the perforation. The repair of TM remained stable throughout the follow-up period of at least 6 months in all patients. These results suggest that PGA sheets have the potential to secure fascia grafts and to guide the epithelialization of new tissue.
我们使用聚乙醇酸(PGA)片作为支撑材料,替代纤维蛋白胶或明胶海绵,以加固鼓膜穿孔修复的筋膜。在 6 例患者中,我们采用下置法将 PGA 片置于筋膜移植物的外侧。在每种情况下,PGA 片在术后 1 周内已被软化并与筋膜融合。在术后 2 至 3 周,PGA 片的部分已脱水并从筋膜上脱离,在其下显示出一个新的有上皮化的鼓膜。最终,PGA 片消失,在术后 4 至 5 周时完全上皮化,穿孔成功闭合。在所有患者的至少 6 个月的随访期内,鼓膜修复保持稳定。这些结果表明 PGA 片具有固定筋膜移植物和引导新组织上皮化的潜力。