完整组织的二维光谱：与COSY相比，同核Hartmann-Hahn光谱提供了更高的灵敏度和信息含量。

Two-dimensional spectra of intact tissue: homonuclear Hartmann-Hahn spectroscopy provides increased sensitivity and information content as compared to COSY.

作者信息

Alonso J, Arús C, Westler W M, Markley J L

机构信息

Department of Biooquímica i Biologia Molecular, Facultat de Ciències, Universitat Autònoma de Barcelona, Spain.

出版信息

Magn Reson Med. 1990 Jul;15(1):142-51. doi: 10.1002/mrm.1910150116.

DOI:10.1002/mrm.1910150116

PMID:2374494

Abstract

Hartmann-Hahn (HOHAHA) spectroscopy led to good definition of proton spin systems of metabolites such as lactate, (phospho) creatine, and carnosine from a 3-g sample of excised frog gastrocnemius muscle in a 17-min experiment. The sign of the HOHAHA cross-peak intensity appears to provide additional information about interactions between metabolites and their protein binding sites.

摘要

哈特曼-哈恩（HOHAHA）光谱法在17分钟的实验中，能很好地界定来自3克切除的青蛙腓肠肌样本中乳酸、（磷酸）肌酸和肌肽等代谢物的质子自旋系统。HOHAHA交叉峰强度的符号似乎能提供有关代谢物与其蛋白质结合位点之间相互作用的额外信息。