H3K27me3和H3K9me3组蛋白修饰的招募及其生物学后果
Recruitment and biological consequences of histone modification of H3K27me3 and H3K9me3.
作者信息
Kim Joomyeong, Kim Hana
机构信息
Department of Biological Sciences, Louisiana State University, Baton Rouge, LA 70803, USA.
出版信息
ILAR J. 2012;53(3-4):232-9. doi: 10.1093/ilar.53.3-4.232.
Abstract
Two histone marks, H3K27me3 and H3K9me3, are well known for their repressive roles in the genic and nongenic regions of metazoan genomes. Several protein complexes are known to be responsible for generating these marks, including polycomb repression complex 2 and several H3K9 methylases. Recent studies have shown that the targeting of these histone-modifying complexes within mammalian genomes may be mediated through several DNA-binding proteins, including AEBP2, JARID2, and YY1. In this review, we discuss the potential targeting mechanisms in light of the recent results that have been derived from genome-wide chromatin immunoprecipitation sequencing data and the in vivo functions of these two histone marks in light of the results derived from mouse and human genetic studies.
摘要
两种组蛋白标记，H3K27me3和H3K9me3，因其在后生动物基因组的基因区域和非基因区域中的抑制作用而广为人知。已知有几种蛋白质复合物负责产生这些标记，包括多梳抑制复合物2和几种H3K9甲基转移酶。最近的研究表明，这些组蛋白修饰复合物在哺乳动物基因组中的靶向作用可能是通过几种DNA结合蛋白介导的，包括AEBP2、JARID2和YY1。在这篇综述中，我们根据全基因组染色质免疫沉淀测序数据得出的最新结果，讨论潜在的靶向机制，并根据小鼠和人类遗传学研究的结果，讨论这两种组蛋白标记的体内功能。
相似文献
1
Recruitment and biological consequences of histone modification of H3K27me3 and H3K9me3.H3K27me3和H3K9me3组蛋白修饰的招募及其生物学后果
ILAR J. 2012;53(3-4):232-9. doi: 10.1093/ilar.53.3-4.232.
2
Polycomb recruitment at the Class II transactivator gene.II类反式激活因子基因处的多梳蛋白招募
Mol Immunol. 2015 Oct;67(2 Pt B):482-91. doi: 10.1016/j.molimm.2015.08.003. Epub 2015 Aug 15.
3
JARID2 and AEBP2 regulate PRC2 in the presence of H2AK119ub1 and other histone modifications.JARID2 和 AEBP2 在 H2AK119ub1 和其他组蛋白修饰的存在下调节 PRC2。
Science. 2021 Jan 22;371(6527). doi: 10.1126/science.abc3393.
4
Yin Yang 1-mediated epigenetic silencing of tumour-suppressive microRNAs activates nuclear factor-κB in hepatocellular carcinoma.阴阳1介导的肿瘤抑制性微小RNA的表观遗传沉默激活肝细胞癌中的核因子κB
J Pathol. 2016 Apr;238(5):651-64. doi: 10.1002/path.4688.
5
C10ORF12 modulates PRC2 histone methyltransferase activity and H3K27me3 levels.C10ORF12 调节 PRC2 组蛋白甲基转移酶活性和 H3K27me3 水平。
Acta Pharmacol Sin. 2019 Nov;40(11):1457-1465. doi: 10.1038/s41401-019-0247-3. Epub 2019 Jun 11.
6
PRC2.1 and PRC2.2 Synergize to Coordinate H3K27 Trimethylation.PRC2.1 和 PRC2.2 协同作用以协调 H3K27 三甲基化。
Mol Cell. 2019 Nov 7;76(3):437-452.e6. doi: 10.1016/j.molcel.2019.08.012. Epub 2019 Sep 11.
7
Unique Structural Platforms of Suz12 Dictate Distinct Classes of PRC2 for Chromatin Binding.Suz12 的独特结构平台决定了 PRC2 与染色质结合的不同类别。
Mol Cell. 2018 Mar 1;69(5):840-852.e5. doi: 10.1016/j.molcel.2018.01.039.
8
Redistribution of H3K27me3 upon DNA hypomethylation results in de-repression of Polycomb target genes.DNA 低甲基化时 H3K27me3 的重新分布导致多梳靶基因的去抑制。
Genome Biol. 2013 Mar 25;14(3):R25. doi: 10.1186/gb-2013-14-3-r25.
9
Sporadic DUX4 expression in FSHD myocytes is associated with incomplete repression by the PRC2 complex and gain of H3K9 acetylation on the contracted D4Z4 allele.在 FSHD 肌细胞中，散发性 DUX4 表达与 PRC2 复合物的不完全抑制以及收缩的 D4Z4 等位基因上 H3K9 乙酰化的获得有关。
Epigenetics Chromatin. 2018 Aug 20;11(1):47. doi: 10.1186/s13072-018-0215-z.
10
Histone methylation by PRC2 is inhibited by active chromatin marks.PRC2 介导的组蛋白甲基化受活性染色质标记抑制。
Mol Cell. 2011 May 6;42(3):330-41. doi: 10.1016/j.molcel.2011.03.025.
引用本文的文献
1
The Crucial Role of Epigenetic Modifications in Wharton's Jelly Stem Cells.表观遗传修饰在脐带胶质干细胞中的关键作用
Int J Mol Sci. 2025 Jul 24;26(15):7169. doi: 10.3390/ijms26157169.
2
Comprehensive multimodal and multiomic profiling reveals epigenetic and transcriptional reprogramming in lung tumors.综合多模态和多组学分析揭示了肺肿瘤中的表观遗传和转录重编程。
Commun Biol. 2025 Mar 31;8(1):527. doi: 10.1038/s42003-025-07954-8.
3
Regulatory Roles of SWI/SNF Chromatin Remodeling Complexes in Immune Response and Inflammatory Diseases.SWI/SNF染色质重塑复合体在免疫反应和炎症性疾病中的调控作用
Clin Rev Allergy Immunol. 2024 Dec 30;68(1):2. doi: 10.1007/s12016-024-09011-4.
4
CHD6 eviction of promoter nucleosomes maintains housekeeping transcriptional program in prostate cancer.冠心病6号蛋白对启动子核小体的驱逐维持前列腺癌的管家转录程序。
Mol Ther Nucleic Acids. 2024 Nov 16;35(4):102397. doi: 10.1016/j.omtn.2024.102397. eCollection 2024 Dec 10.
5
Deep5hmC: predicting genome-wide 5-hydroxymethylcytosine landscape via a multimodal deep learning model.Deep5hmC：通过多模态深度学习模型预测全基因组 5-羟甲基胞嘧啶景观。
Bioinformatics. 2024 Sep 2;40(9). doi: 10.1093/bioinformatics/btae528.
6
Adolescent binge ethanol impacts H3K9me3-occupancy at synaptic genes and the regulation of oligodendrocyte development.青少年暴饮乙醇会影响突触基因处的H3K9me3占据情况以及少突胶质细胞发育的调控。
Front Mol Neurosci. 2024 May 22;17:1389100. doi: 10.3389/fnmol.2024.1389100. eCollection 2024.
7
Age-dependent regulation of ELP1 exon 20 splicing in Familial Dysautonomia by RNA Polymerase II kinetics and chromatin structure.年龄依赖性调节 RNA 聚合酶 II 动力学和染色质结构在家族性自主神经异常症中 ELP1 外显子 20 的剪接。
PLoS One. 2024 Jun 3;19(6):e0298965. doi: 10.1371/journal.pone.0298965. eCollection 2024.
8
H4K20me3, H3K4me2 and H3K9me2 mediate the effect of ER on prognosis in breast cancer.H4K20me3、H3K4me2和H3K9me2介导雌激素受体对乳腺癌预后的影响。
Epigenetics. 2024 Dec;19(1):2343593. doi: 10.1080/15592294.2024.2343593. Epub 2024 Apr 21.
9
Deep5hmC: Predicting genome-wide 5-Hydroxymethylcytosine landscape via a multimodal deep learning model.深度5-羟甲基胞嘧啶：通过多模态深度学习模型预测全基因组5-羟甲基胞嘧啶图谱
bioRxiv. 2024 Mar 6:2024.03.04.583444. doi: 10.1101/2024.03.04.583444.
10
Dynamic and distinct histone modifications facilitate human trophoblast lineage differentiation.动态且独特的组蛋白修饰促进人滋养层谱系分化。
Sci Rep. 2024 Feb 24;14(1):4505. doi: 10.1038/s41598-024-55189-0.
本文引用的文献
1
Aebp2 as an epigenetic regulator for neural crest cells.Aebp2 作为神经嵴细胞的表观遗传调节剂。
PLoS One. 2011;6(9):e25174. doi: 10.1371/journal.pone.0025174. Epub 2011 Sep 19.
2
Association of Rex-1 to target genes supports its interaction with Polycomb function.Rex-1与靶基因的关联支持其与多梳蛋白功能的相互作用。
Stem Cell Res. 2011 Jul;7(1):1-16. doi: 10.1016/j.scr.2011.02.005. Epub 2011 Mar 2.
3
Characterization of the contradictory chromatin signatures at the 3' exons of zinc finger genes.锌指基因 3' 外显子中矛盾的染色质特征分析。
PLoS One. 2011 Feb 15;6(2):e17121. doi: 10.1371/journal.pone.0017121.
4
The Polycomb complex PRC2 and its mark in life.多梳抑制复合物 PRC2 及其在生命中的标记。
Nature. 2011 Jan 20;469(7330):343-9. doi: 10.1038/nature09784.
5
GC-rich sequence elements recruit PRC2 in mammalian ES cells.富含 GC 的序列元件在哺乳动物胚胎干细胞中招募 PRC2。
PLoS Genet. 2010 Dec 9;6(12):e1001244. doi: 10.1371/journal.pgen.1001244.
6
Inactivating mutations of the histone methyltransferase gene EZH2 in myeloid disorders.在髓系疾病中，组蛋白甲基转移酶基因 EZH2 的失活突变。
Nat Genet. 2010 Aug;42(8):722-6. doi: 10.1038/ng.621. Epub 2010 Jul 4.
7
Proviral silencing in embryonic stem cells requires the histone methyltransferase ESET.原病毒在胚胎干细胞中的沉默需要组蛋白甲基转移酶 ESET。
Nature. 2010 Apr 8;464(7290):927-31. doi: 10.1038/nature08858. Epub 2010 Feb 17.
8
Jarid2 and PRC2, partners in regulating gene expression.Jarid2 和 PRC2，调控基因表达的合作伙伴。
Genes Dev. 2010 Feb 15;24(4):368-80. doi: 10.1101/gad.1886410. Epub 2010 Feb 1.
9
KAP1 controls endogenous retroviruses in embryonic stem cells.KAP1 控制胚胎干细胞中的内源性逆转录病毒。
Nature. 2010 Jan 14;463(7278):237-40. doi: 10.1038/nature08674.
10
JARID2 regulates binding of the Polycomb repressive complex 2 to target genes in ES cells.JARID2 调节多梳抑制复合物 2 与 ES 细胞中靶基因的结合。
Nature. 2010 Mar 11;464(7286):306-10. doi: 10.1038/nature08788.
Zotero 插件