癌症表观遗传学：简要综述。
Cancer epigenetics: a brief review.
作者信息
Virani Shama, Colacino Justin A, Kim Jung H, Rozek Laura S
出版信息
ILAR J. 2012;53(3-4):359-69. doi: 10.1093/ilar.53.3-4.359.
Abstract
Cancer is a disease that results from the successive accumulation of genetic and epigenetic alterations. Despite intense study, many unanswered questions about the nature of the contribution of epigenetic changes to carcinogenesis remain. In this review, we describe principles of epigenetics as they relate to our current understanding of carcinogenesis. There are a number of in vivo models of specific pathways of carcinogenesis that are very useful for the characterization of epigenetic mechanisms that link environmental exposures or genetic susceptibility and cancer progression. Because epigenetic alterations are thought to be reversible, they offer great promise for treatment of cancer. The use of animal models to evaluate the effects of decitabine and zebularine has elucidated the mechanisms of action and indicated the potential for these types of treatment. Ultimately, the greatest challenge lies in the integration of laboratory and epidemiologic data to best prevent and treat this deadly disease.
摘要
癌症是一种由基因和表观遗传改变的连续积累导致的疾病。尽管进行了深入研究，但关于表观遗传变化对致癌作用贡献的本质仍有许多未解决的问题。在本综述中，我们描述了表观遗传学原理，因为它们与我们目前对致癌作用的理解相关。有许多致癌作用特定途径的体内模型，对于表征将环境暴露或遗传易感性与癌症进展联系起来的表观遗传机制非常有用。由于表观遗传改变被认为是可逆的，它们为癌症治疗提供了巨大的希望。使用动物模型评估地西他滨和泽布替尼的效果已经阐明了其作用机制，并表明了这类治疗的潜力。最终，最大的挑战在于整合实验室和流行病学数据，以最好地预防和治疗这种致命疾病。
相似文献
1
Cancer epigenetics: a brief review.癌症表观遗传学：简要综述。
ILAR J. 2012;53(3-4):359-69. doi: 10.1093/ilar.53.3-4.359.
2
Epigenetic modifications in cancer.癌症中的表观遗传修饰。
Clin Genet. 2012 Apr;81(4):303-11. doi: 10.1111/j.1399-0004.2011.01809.x. Epub 2011 Dec 8.
3
Epigenetics in lung cancer diagnosis and therapy.表观遗传学在肺癌诊断与治疗中的应用
Cancer Metastasis Rev. 2015 Jun;34(2):229-41. doi: 10.1007/s10555-015-9563-3.
4
Cancer epigenetics: above and beyond.癌症表观遗传学：超越传统认识。
Toxicol Mech Methods. 2011 May;21(4):275-88. doi: 10.3109/15376516.2011.562671.
5
Epigenetic regulation and cancer (review).表观遗传学调控与癌症（综述）。
Oncol Rep. 2014 Feb;31(2):523-32. doi: 10.3892/or.2013.2913. Epub 2013 Dec 11.
6
[Epigenetics in tumorigenesis: advances and clinical implications].[肿瘤发生中的表观遗传学：进展与临床意义]
Beijing Da Xue Xue Bao Yi Xue Ban. 2012 Oct 18;44(5):701-7.
7
Epigenetic regulation of peroxiredoxins: Implications in the pathogenesis of cancer.过氧化物氧还蛋白的表观遗传调控：对癌症发病机制的影响
Exp Biol Med (Maywood). 2017 Jan;242(2):140-147. doi: 10.1177/1535370216669834. Epub 2016 Oct 4.
8
The role of genetics and epigenetics in the pathogenesis of systemic sclerosis.遗传学和表观遗传学在系统性硬化症发病机制中的作用。
Nat Rev Rheumatol. 2014 Nov;10(11):671-81. doi: 10.1038/nrrheum.2014.128. Epub 2014 Aug 19.
9
Epigenetically regulated microRNAs in Alzheimer's disease.阿尔茨海默病中受表观遗传调控的微小RNA
Neurobiol Aging. 2014 Apr;35(4):731-45. doi: 10.1016/j.neurobiolaging.2013.10.082. Epub 2013 Oct 18.
10
The growing role of epigenetics in childhood cancers.表观遗传学在儿童癌症中的作用日益凸显。
Curr Opin Pediatr. 2020 Feb;32(1):67-75. doi: 10.1097/MOP.0000000000000867.
引用本文的文献
1
Placental and immune cell DNA methylation reference panel for bulk tissue cell composition estimation in epidemiological studies.用于流行病学研究中大块组织细胞组成估计的胎盘和免疫细胞DNA甲基化参考面板。
Epigenetics. 2024 Dec;19(1):2437275. doi: 10.1080/15592294.2024.2437275. Epub 2024 Dec 8.
2
CBX4 plays a bidirectional role in transcriptional regulation and lung adenocarcinoma progression.CBX4 在转录调控和肺腺癌进展中发挥双向作用。
Cell Death Dis. 2024 May 30;15(5):378. doi: 10.1038/s41419-024-06745-z.
3
Rational Computational Approaches in Drug Discovery: Potential Inhibitors for Allosteric Regulation of Mutant Isocitrate Dehydrogenase-1 Enzyme in Cancers.理性计算方法在药物发现中的应用：用于癌症中突变型异柠檬酸脱氢酶-1 酶变构调节的潜在抑制剂。
Molecules. 2023 Mar 2;28(5):2315. doi: 10.3390/molecules28052315.
4
Association of childhood and adolescence obesity with incidence and mortality of adulthood cancers. A systematic review and meta-analysis.儿童和青少年肥胖与成年癌症发病率和死亡率的关联。系统评价和荟萃分析。
Front Endocrinol (Lausanne). 2023 Jan 19;14:1069164. doi: 10.3389/fendo.2023.1069164. eCollection 2023.
5
Modulation of DNA/RNA Methylation by Small-Molecule Modulators and Their Implications in Cancer.小分子调节剂对 DNA/RNA 甲基化的调控及其在癌症中的意义。
Subcell Biochem. 2022;100:557-579. doi: 10.1007/978-3-031-07634-3_17.
6
Hypoxia Affects HIF-1/LDH-A Signaling Pathway by Methylation Modification and Transcriptional Regulation in Japanese Flounder ().缺氧通过甲基化修饰和转录调控影响牙鲆的HIF-1/LDH-A信号通路。
Biology (Basel). 2022 Aug 18;11(8):1233. doi: 10.3390/biology11081233.
7
Development and evaluation of a pH-responsive and water-soluble drug delivery system based on smart polymer coating of graphene nanosheets: an study.基于石墨烯纳米片智能聚合物涂层的pH响应性水溶性药物递送系统的开发与评价：一项研究。
RSC Adv. 2020 Aug 21;10(52):31106-31114. doi: 10.1039/d0ra06705a.
8
KISS-1, Mediated by Promoter Methylation, Suppresses Esophageal Squamous Cell Carcinoma Metastasis via MMP2/9/MAPK Axis.KISS-1 通过启动子甲基化抑制 MMP2/9/MAPK 轴抑制食管鳞癌细胞转移。
Dig Dis Sci. 2022 Oct;67(10):4780-4796. doi: 10.1007/s10620-021-07335-1. Epub 2022 Jan 7.
9
Bringing precision oncology to cellular resolution with single-cell genomics.单细胞基因组学带来细胞分辨率的精准肿瘤学。
Clin Exp Metastasis. 2022 Feb;39(1):79-83. doi: 10.1007/s10585-021-10129-4. Epub 2021 Nov 22.
10
Aberrant super-enhancer-driven oncogene ENC1 promotes the radio-resistance of breast carcinoma.异常的超级增强子驱动的癌基因 ENC1 促进乳腺癌的放射抵抗性。
Cell Death Dis. 2021 Aug 6;12(8):777. doi: 10.1038/s41419-021-04060-5.
本文引用的文献
1
Valproic acid inhibits prostate cancer cell migration by up-regulating E-cadherin expression.丙戊酸通过上调E-钙黏蛋白的表达来抑制前列腺癌细胞的迁移。
Pharmazie. 2011 Aug;66(8):614-8.
2
DNA demethylating antineoplastic strategies: a comparative point of view.DNA去甲基化抗肿瘤策略：比较视角
Genes Cancer. 2010 Mar;1(3):197-209. doi: 10.1177/1947601910365081.
3
Genome-wide methylation and expression differences in HPV(+) and HPV(-) squamous cell carcinoma cell lines are consistent with divergent mechanisms of carcinogenesis.HPV(+) 和 HPV(-) 鳞状细胞癌细胞系的全基因组甲基化和表达差异与不同的致癌机制一致。
Epigenetics. 2011 Jun;6(6):777-87. doi: 10.4161/epi.6.6.16216. Epub 2011 Jun 1.
4
Chromosome-wide DNA methylation analysis predicts human tissue-specific X inactivation.全染色体 DNA 甲基化分析预测人类组织特异性 X 染色体失活。
Hum Genet. 2011 Aug;130(2):187-201. doi: 10.1007/s00439-011-1007-8. Epub 2011 May 20.
5
Lysine-specific demethylase 1 is highly expressed in solitary fibrous tumors, synovial sarcomas, rhabdomyosarcomas, desmoplastic small round cell tumors, and malignant peripheral nerve sheath tumors.赖氨酸特异性去甲基化酶 1 在孤立性纤维瘤、滑膜肉瘤、横纹肌肉瘤、促结缔组织增生性小圆细胞肿瘤和恶性外周神经鞘瘤中高度表达。
Hum Pathol. 2011 Nov;42(11):1667-75. doi: 10.1016/j.humpath.2010.12.025. Epub 2011 Apr 29.
6
Evidence that the histone methyltransferase Dot1 mediates global genomic repair by methylating histone H3 on lysine 79.证据表明，组蛋白甲基转移酶 Dot1 通过甲基化组蛋白 H3 赖氨酸 79 来介导全局基因组修复。
J Biol Chem. 2011 May 20;286(20):17530-5. doi: 10.1074/jbc.M111.241570. Epub 2011 Apr 1.
7
The histone methyltransferase SETDB1 is recurrently amplified in melanoma and accelerates its onset.组蛋白甲基转移酶 SETDB1 在黑色素瘤中经常扩增，并加速其发病。
Nature. 2011 Mar 24;471(7339):513-7. doi: 10.1038/nature09806.
8
Deletion of the inhibitor of growth 4 (ING4) tumor suppressor gene is prevalent in human epidermal growth factor 2 (HER2)-positive breast cancer.生长抑制因子 4（ING4）肿瘤抑制基因缺失在人表皮生长因子 2（HER2）阳性乳腺癌中普遍存在。
Hum Pathol. 2011 Jul;42(7):983-90. doi: 10.1016/j.humpath.2010.10.012. Epub 2011 Feb 11.
9
Epigenetic aberrations during oncogenesis.致癌过程中的表观遗传异常。
Cell Mol Life Sci. 2011 May;68(10):1681-702. doi: 10.1007/s00018-010-0624-z. Epub 2011 Jan 20.
10
Histone H3 lysine 79 methyltransferase Dot1 is required for immortalization by MLL oncogenes.组蛋白 H3 赖氨酸 79 甲基转移酶 Dot1 对于 MLL 癌基因的永生化是必需的。
Cancer Res. 2010 Dec 15;70(24):10234-42. doi: 10.1158/0008-5472.CAN-10-3294.
Zotero 插件