波兰丙型肝炎病毒基因型的分布情况。
Distribution of HCV genotypes in Poland.
作者信息
Panasiuk Anatol, Flisiak Robert, Mozer-Lisewska Iwona, Adamek Agnieszka, Tyczyno Małgorzata, Halota Waldemar, Pawłowska Małgorzata, Stańczak Janusz, Berak Hanna, Wawrzynowicz-Syczewska Marta, Boroń-Kaczmarska Anna, Łapiński Tadeusz Wojciech, Grzeszczuk Anna, Piekarska Anna, Tomasiewicz Krzysztof, Jabłkowski Maciej, Kryczka Wiesław, Zarebska-Michaluk Dorota, Stepień Piotr, Garlicki Aleksander Michał, Kozłowska Joanna, Wiercińska-Drapało Alicja, Zasik Ewelina, Mazur Waldemar, Dobracka Bozena, Dobracki Witold, Simon Krzysztof, Ryzko Józef, Pawłowska Joanna, Dzierzanowska-Fangrat Katarzyna, Januszkiewicz-Lewandowska Danuta, Szenborn Leszek, Zaleska Izabela, Rokitka Maria, Strawińska Elzbieta, Balinowska Katarzyna, Smiatacz Tomasz, Stalke Piotr, Sikorska Katarzyna, Lakomy Anna, Zdrojewski Maciej, Lachowicz Anna
机构信息
Klinika Chorób Zakaźnych i Hepatologii UM w Białymstoku, Poland.
出版信息
Przegl Epidemiol. 2013;67(1):11-6, 99-103.
UNLABELLED
Available data on prevalence of HCV genotypes in Poland are insufficient. The aim of the study was the analysis of distribution of HCV genotypes in Poland over the period of recent 10 years regarding the age of patients and the regions of the country.
MATERIAL AND METHODS
Analysis of HCV genotypes in Poland was carried out between 2003 and 2012, and included 14 651 patients from 22 centers where patients with chronic viral hepatitis C are diagnosed and treated. Genotypes were analyzed in age groups (< 20 years of age, 20-40 years of age, > 40 years of age) as well as in populations of HBV and HIV co-infections.
RESULTS
Genotype (G) 1 infection was demonstrated in 79.4%, G2 -0.1%, G3- 13.8%, G4- 4.9%, G6-0.09% and mixed infections in 1.6%. There was no infection with genotype 5. The highest prevalence of G1 was observed in the Łódzkie voivodship (89.2%) and the Slaskie voivodship (86.7%) while the lowest one in the Warmińsko-mazurskie (62.0%) and the Podlaskie voivodships (68.2%). Genotype 3 most commonly occurs in the Warmińsko-mazurskie (28.1%), and the Podlaskie voivodships (23.0%) and is least common in the Małopolskie (7.9%) and the Łódzkie voivodships (9.0%). Genotype 4 is more common in the Kujawsko-pomorskie (11.7%) and the Podlaskie voivodships (8.6%) and relatively less common in the Lubelskie (1.1%) and the Łódzkie voivodships (1.8%). Prevalence of G1 infection in 2003-2004 was 72% and increased up to 85.6% in 2011-2012, that was accompanied by decrease of G3 prevalence from 17% to 8% in this period. In HBV co-infected (n = 83), G1 infection was demonstrated in 85.5%, G3 - in 7.2%, G4 -4.8%, and mixed genotypes in 6%. Among HIV co-infected (n = 391), a much lower prevalence of G1 (33.0%) and a high of G3 (40.4%) as well as G4 (24.0%) were observed.
CONCLUSIONS
There is a geographic variability of HCV genotypes prevalence in Poland. Increase of HCV G1 infections and decrease of G3 and G4 were observed in the last 10 years. Genotypes G3 and G4 occur more often in HCV/HIV co-infected than in HCV mono-infected patients.
未标注
波兰丙型肝炎病毒（HCV）基因型流行率的现有数据不足。本研究的目的是分析近10年来波兰HCV基因型在患者年龄和国家地区方面的分布情况。
材料与方法
对2003年至2012年间波兰的HCV基因型进行分析，纳入了来自22个中心的14651例患者，这些中心负责诊断和治疗慢性丙型病毒性肝炎患者。对年龄组（<20岁、20 - 40岁、>40岁）以及HBV和HIV合并感染人群的基因型进行分析。
结果
基因型（G）1感染占79.4%，G2 - 0.1%，G3 - 13.8%，G4 - 4.9%，G6 - 0.09%，混合感染占1.6%。未发现基因型5感染。在罗兹省（89.2%）和西里西亚省（86.7%）观察到G1的最高流行率，而在瓦尔米亚 - 马祖里省（62.0%）和波德拉斯基省（68.2%）最低。基因型3最常见于瓦尔米亚 - 马祖里省（28.1%）和波德拉斯基省（23.0%），在小波兰省（7.9%）和罗兹省（9.0%）最不常见。基因型4在库亚维 - 波美拉尼亚省（11.7%）和波德拉斯基省（8.6%）更常见，在卢布林省（1.1%）和罗兹省（1.8%）相对较少见。2003 - 2004年G1感染的流行率为72%，到2011 - 2012年增至85.6%，同期G3的流行率从17%降至8%。在HBV合并感染患者（n = 83）中，G1感染占85.5%，G3 - 占7.2%，G4 - 占4.8%，混合基因型占6%。在HIV合并感染患者（n = 391）中，观察到G1的流行率低得多（33.0%），G3（40.4%）和G4（24.0%）的流行率较高。
结论
波兰HCV基因型流行率存在地理差异。在过去10年中观察到HCV G1感染增加，G3和G4减少。与HCV单一感染患者相比，G3和G4基因型在HCV/HIV合并感染患者中更常出现。
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