Laboratorio de Sueño, Facultad de Psicología, UNAM, México 04510, Mexico.
Clin Neurophysiol. 2013 Oct;124(10):1959-69. doi: 10.1016/j.clinph.2013.04.334. Epub 2013 Jun 6.
To investigate the acute role of the corpus callosum in inter- and intrahemispheric temporal coupling.
Intraoperative electrocorticography (ECoG) makes it possible to investigate the acute role of the corpus callosum in cortical temporal coupling, or synchrony, without additional surgical intervention, thus avoiding the confounding effects of scalp recordings and the long-term reorganization of functional connectivity. ECoGs were recorded in three patients during callosotomies. Bilateral electrode grids were placed over the frontal cortex. ECoGs were recorded immediately before and after performing the anterior two-thirds callosal transection, were digitalized at a sampling rate of 512Hz, inspected for artifacts, and later analyzed offline. Cross-correlation between inter- and intrahemispheric electrode pairs were obtained for 1Hz bins and special broad bands obtained by principal component analysis for each patient pre- and post-callosotomy.
A statistically significant change was observed in intrahemispheric temporal coupling between electrode pairs that exceeded the confidence limit of correlation.
Present results show that interrupting the influence of the corpus callosum has an acute effect on intrahemispheric activity by decreasing temporal coupling between cortical areas.
Intrahemispheric temporal coupling does not depend exclusively on ipsilateral cortico-cortical pathways or on subcortical influences, but also on callosal pathways.
研究胼胝体在半球间和半球内颞叶耦合中的急性作用。
术中脑电图（ECoG）使我们能够在不进行额外手术干预的情况下研究胼胝体在皮质颞叶耦合或同步中的急性作用，从而避免头皮记录和功能连接的长期重组的混杂影响。在胼胝体切开术中记录了 3 名患者的 ECoG。双侧电极网格放置在前额皮质上。在进行前 2/3 胼胝体横断术之前和之后记录 ECoG，以 512Hz 的采样率数字化，检查伪影，然后离线分析。在每个患者的胼胝体切开术之前和之后，获得了 1Hz -bin 的跨半球和通过主成分分析获得的特殊宽带的电极对之间的互相关。
观察到超过相关置信限的电极对之间的半球内颞叶耦合发生了统计学上显著的变化。
目前的结果表明，中断胼胝体的影响通过降低皮质区域之间的时间耦合对半球内活动具有急性作用。
半球内时间耦合不仅依赖于同侧皮质-皮质通路或皮质下影响，还依赖于胼胝体通路。
