Matsuhashi Ako, Matsuo Takeshi, Kumada Satoko
Department of Neurosurgery, Tokyo Metropolitan Neurological Hospital, 2-6-1 Musashidai, Fuchu-shi, Tokyo 183-0042, Japan.
Department of Neuropediatrics, Tokyo Metropolitan Neurological Hospital, 2-6-1 Musashidai, Fuchu-shi, Tokyo 183-0042, Japan.
Epilepsy Behav Rep. 2022 Jan 22;18:100525. doi: 10.1016/j.ebr.2022.100525. eCollection 2022.
Corpus callosotomy (CC) has been reported to be effective in reducing generalized seizures in patients with drug-resistant epilepsies. However, efficacy is measured only by seizure frequency, without any electrophysiological guidance. Herein, we conducted a quantitative analysis of interhemispheric functional connectivity using inter-electrode coherence of scalp electroencephalogram (EEG) in a clinical case of subcortical band heterotopia to evaluate its relationship with seizure frequency. In our case, seizure frequency decreased significantly after posterior CC but not after anterior CC. Inter-electrode coherence also decreased after posterior CC, suggesting it correlated with seizure frequency. This case study supports the use of inter-electrode coherence as an electrophysiological tool that is useful as predictive factor in evaluating the effectiveness of CC.
据报道，胼胝体切开术（CC）在减少耐药性癫痫患者的全身性癫痫发作方面有效。然而，疗效仅通过癫痫发作频率来衡量，没有任何电生理指导。在此，我们对一例皮质下带状异位症临床病例，利用头皮脑电图（EEG）电极间相干性对半球间功能连接进行了定量分析，以评估其与癫痫发作频率的关系。在我们的病例中，后胼胝体切开术后癫痫发作频率显著降低，但前胼胝体切开术后未降低。后胼胝体切开术后电极间相干性也降低，表明其与癫痫发作频率相关。本病例研究支持将电极间相干性作为一种电生理工具，作为评估胼胝体切开术有效性的预测因素。
