Vaccine and Gene Therapy Institute, Oregon Health & Science University, Beaverton, OR 97006, United States.
Curr Opin Virol. 2013 Jun;3(3):245-50. doi: 10.1016/j.coviro.2013.05.016. Epub 2013 Jun 6.
Rhesus macaque rhadinovirus (RRV) is a gamma-2 herpesvirus that naturally infects rhesus macaque (RM) monkeys and is closely related to human herpesvirus-8 (HHV-8)/Kaposi's sarcoma-associated herpesvirus (KSHV). Infection of immunodeficient RM induces disease in infected RM that resembles KSHV-associated pathologies. Importantly, RRV possesses homologues of KSHV ORFs that are postulated to play a role in disease development. As such, RRV has emerged as a prominent in vivo model system for examining mechanisms of infection and disease of these pathogenic herpesviruses, and has provided unique insight into how these viruses cause disease.
恒河猴疱疹病毒（RRV）是一种γ-2 疱疹病毒，自然感染恒河猴（RM），与人类疱疹病毒 8 型（HHV-8）/卡波济肉瘤相关疱疹病毒（KSHV）密切相关。免疫缺陷的 RM 感染会导致受感染的 RM 发生疾病，类似于 KSHV 相关的病理。重要的是，RRV 具有 KSHV ORF 的同源物，这些同源物被认为在疾病发展中发挥作用。因此，RRV 已成为研究这些致病性疱疹病毒感染和疾病机制的重要体内模型系统，并为这些病毒如何引起疾病提供了独特的见解。
