一种激进的信号激活了长寿的表观遗传调控。

A radical signal activates the epigenetic regulation of longevity.

机构信息

Department of Medical and Forensic Biotechnology (DiBiMeF), University of Palermo, via Divisi 83, 90133 Palermo, Italy; Longevity Institute, School of Gerontology and Department of Biological Sciences, University of Southern California, 3715 McClintock Avenue, Los Angeles, CA 90089, USA.

Longevity Institute, School of Gerontology and Department of Biological Sciences, University of Southern California, 3715 McClintock Avenue, Los Angeles, CA 90089, USA.

出版信息

Cell Metab. 2013 Jun 4;17(6):812-813. doi: 10.1016/j.cmet.2013.05.015.

DOI:10.1016/j.cmet.2013.05.015

PMID:23747240

Abstract

Hormesis is an adaptive stress response implicated in longevity regulation. Schroeder et al. (2013) have now connected stress, epigenetic changes, and aging in yeast by showing that mitochondria-derived reactive oxygen species modulate the chromatin binding capacity of the histone demethylase Rph1p at subtelomeres, resulting in lifespan extension.

摘要

胁迫反应是一种与长寿调控有关的适应性应激反应。Schroeder 等人（2013 年）通过证明线粒体来源的活性氧调节着端粒处组蛋白去甲基酶 Rph1p 的染色质结合能力，从而延长酵母的寿命，将应激、表观遗传变化和衰老联系起来。