Taormina Giusi, Mirisola Mario G
Dipartimento di Biopatologia e Biotecnologie Mediche e Forensi (DiBiMeF), Università di Palermo, Via Divisi 83, 90133 Palermo, Italy.
Biomed Res Int. 2014;2014:308690. doi: 10.1155/2014/308690. Epub 2014 May 6.
Calorie restriction (CR), which usually refers to a 20-40% reduction in calorie intake, can effectively prolong lifespan preventing most age-associated diseases in several species. However, recent data from both human and nonhumans point to the ratio of macronutrients rather than the caloric intake as a major regulator of both lifespan and health-span. In addition, specific components of the diet have recently been identified as regulators of some age-associated intracellular signaling pathways in simple model systems. The comprehension of the mechanisms underpinning these findings is crucial since it may increase the beneficial effects of calorie restriction making it accessible to a broader population as well.
热量限制（CR）通常指热量摄入减少20%-40%，它能有效延长多种物种的寿命，预防大多数与年龄相关的疾病。然而，最近来自人类和非人类的数据表明，常量营养素的比例而非热量摄入是寿命和健康寿命的主要调节因素。此外，最近在简单模型系统中已确定饮食中的特定成分是一些与年龄相关的细胞内信号通路的调节因子。理解这些发现背后的机制至关重要，因为这可能会增强热量限制的有益效果，使其也能惠及更广泛的人群。
