Araoud Manel, Mhenni Hamida, Hellara Ilhem, Hellara Olfa, Neffati Fadoua, Douki Wahiba, Mili Marwa, Saffar Hammouda, Najjar Mohamed Fadhel
Laboratoire de biochimie-toxicologie, Hôpital universitaire Fattouma Bourguiba, Monastir, Tunisie.
Ann Biol Clin (Paris). 2013 May-Jun;71(3):293-8. doi: 10.1684/abc.2013.0819.
Plasma cholinesterase activity (ChE) may vary in some pathological circumstances. We studied the changes in activity of this enzyme according to the type of liver injury, to assess the interest of this parameter in the diagnosis of liver diseases. Our study was performed on 102 patients with different liver diseases and 53 healthy controls. The ChE activity was lower in patients compared to control group (p < 0.0001), and more pronounced in cirrhotic patients compared to those suffering from hepatitis. Elevated activities of AST, ALT, GGT and ALP and bilirubinemia, and decreased albuminemia were noted in patients compared to controls (p < 0.001). Hypoalbuminemia was significantly important in cirrhotic patients compared to those suffering from cholestasis or hepatitis. A correlation between ChE and bilirubin, albumin and serum protein was found in patients with cirrhosis or those with chronic hepatitis. A significantly lower activity of ChE was found in patients with hepatic insufficiency (HI). In case of suspicion of HI, the prescription of ChE activity could guide or confirm the diagnosis of the impairment.
血浆胆碱酯酶活性（ChE）在某些病理情况下可能会有所不同。我们根据肝损伤类型研究了该酶活性的变化，以评估该参数在肝病诊断中的意义。我们的研究对102例患有不同肝病的患者和53例健康对照者进行。与对照组相比，患者的ChE活性较低（p < 0.0001），与肝炎患者相比，肝硬化患者的ChE活性下降更为明显。与对照组相比，患者的AST、ALT、GGT和ALP活性升高以及胆红素血症增加，白蛋白血症降低（p < 0.001）。与胆汁淤积或肝炎患者相比，肝硬化患者的低白蛋白血症更为显著。在肝硬化患者或慢性肝炎患者中发现ChE与胆红素、白蛋白和血清蛋白之间存在相关性。肝衰竭（HI）患者的ChE活性明显较低。在怀疑有HI的情况下，检测ChE活性可指导或确认损伤的诊断。
