Adama Science & Technology University, Adama, Ethiopia.
Int Immunopharmacol. 2013 Oct;17(2):254-9. doi: 10.1016/j.intimp.2013.05.015. Epub 2013 Jun 6.
Capsaicin (CAP), a constituent of red chilli and red pepper is exposed to exert compelling anticarcinogenic effects. In the present study, we examined the anti-tumorigenic potential of CAP on benzo(a)pyrene-induced mice lung tumorigenesis by analyzing the markers of apoptosis. Intraperitoneal administration of CAP (10mg/kg body weight) to Swiss albino mice suppressed the development of lung carcinoma by amending the protein expressions of apoptotic regulators p53, Bcl-2, Bax and caspase-3. The apoptotic-inducing nature of CAP was further confirmed by DNA agarose gel electrophoresis, transmission electron microscopic study and ethidium bromide/acridine orange staining. The results obtained from the present study show that CAP inhibits the development of mice lung carcinogenesis through its ability to induce apoptosis. Our present findings provide the basis for further clinical exploration of CAP as an anti-carcinogenic compound against lung carcinogenesis.
辣椒素（CAP）是红辣椒和红辣椒的一种成分，已被证明具有很强的抗癌作用。在本研究中，我们通过分析凋亡标志物来研究 CAP 对苯并（a）芘诱导的小鼠肺癌发生的抗肿瘤潜能。腹腔内给予 CAP（10mg/kg 体重）可通过调节凋亡调节剂 p53、Bcl-2、Bax 和 caspase-3 的蛋白表达来抑制肺癌的发生。CAP 的诱导凋亡特性还通过 DNA 琼脂糖凝胶电泳、透射电子显微镜研究和溴化乙锭/吖啶橙染色得到进一步证实。本研究结果表明，CAP 通过诱导细胞凋亡抑制小鼠肺癌的发生。我们的研究结果为进一步探索 CAP 作为一种抗癌化合物用于抑制肺癌发生提供了依据。
