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Hyperpolarization-activated cyclic nucleotide-gated channels and ventricular arrhythmias in heart failure: a novel target for therapy?

作者信息

Dias Priyanthi, Terracciano Cesare M

出版信息

J Am Heart Assoc. 2013 Jun 7;2(3):e000287. doi: 10.1161/JAHA.113.000287.

DOI:10.1161/JAHA.113.000287
PMID:23747794
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC3698796/
Abstract
摘要

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本文引用的文献

1
Increased expression of HCN channels in the ventricular myocardium contributes to enhanced arrhythmicity in mouse failing hearts.心室心肌中 HCN 通道表达增加导致小鼠衰竭心脏心律失常增强。
J Am Heart Assoc. 2013 May 24;2(3):e000150. doi: 10.1161/JAHA.113.000150.
2
New therapeutic targets in cardiology: heart failure and arrhythmia: HCN channels.心脏病学中的新治疗靶点：心力衰竭与心律失常：超极化激活的环核苷酸门控通道
Circulation. 2013 May 14;127(19):1986-96. doi: 10.1161/CIRCULATIONAHA.112.000145.
3
Influence of ivabradine on reverse remodelling during mechanical unloading.异搏定对机械卸载过程中心脏逆重构的影响。
Cardiovasc Res. 2013 Feb 1;97(2):230-9. doi: 10.1093/cvr/cvs318. Epub 2012 Oct 18.
4
Clinical efficacy of ivabradine in patients with inappropriate sinus tachycardia: a prospective, randomized, placebo-controlled, double-blind, crossover evaluation.伊伐布雷定治疗不适当窦性心动过速患者的临床疗效：前瞻性、随机、安慰剂对照、双盲、交叉评估。
J Am Coll Cardiol. 2012 Oct 9;60(15):1323-9. doi: 10.1016/j.jacc.2012.06.031. Epub 2012 Sep 12.
5
Ventricular HCN channels decrease the repolarization reserve in the hypertrophic heart.心室 HCN 通道减少肥厚心脏的复极化储备。
Cardiovasc Res. 2012 Aug 1;95(3):317-26. doi: 10.1093/cvr/cvs184. Epub 2012 May 31.
6
Exploring HCN channels as novel drug targets.探讨 HCN 通道作为新型药物靶点。
Nat Rev Drug Discov. 2011 Nov 18;10(12):903-14. doi: 10.1038/nrd3576.
7
Effects of selective heart rate reduction with ivabradine on left ventricular remodelling and function: results from the SHIFT echocardiography substudy.依伐布雷定对选择性心率降低对左心室重构和功能的影响：SHIFT 超声心动图子研究结果。
Eur Heart J. 2011 Oct;32(20):2507-15. doi: 10.1093/eurheartj/ehr311. Epub 2011 Aug 29.
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Risk stratification for arrhythmic sudden cardiac death: identifying the roadblocks.心律失常性心脏性猝死的风险分层：识别障碍
Circulation. 2011 May 31;123(21):2423-30. doi: 10.1161/CIRCULATIONAHA.110.959734.
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Heart rate reduction with ivabradine prevents the global phenotype of left ventricular remodeling.异搏定可降低心率，预防左心室重构的整体表型。
Am J Physiol Heart Circ Physiol. 2011 Jan;300(1):H366-73. doi: 10.1152/ajpheart.01117.2009. Epub 2010 Oct 15.
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Heart rate as a risk factor in chronic heart failure (SHIFT): the association between heart rate and outcomes in a randomised placebo-controlled trial.心率作为慢性心力衰竭的危险因素（SHIFT）：一项随机安慰剂对照试验中心率与结局的关系。
Lancet. 2010 Sep 11;376(9744):886-94. doi: 10.1016/S0140-6736(10)61259-7.