Department of Gastrointestinal Surgery, Gansu Tumor Hospital, Lanzhou, Gansu 730050, PR China.
Front Biosci (Landmark Ed). 2013 Jun 1;18(3):803-10. doi: 10.2741/4144.
microRNAs (miRNAs) are fundamental gene regulators that can control cell proliferation, differentiation, and apoptosis during tumor development. These molecules can function as oncogenes or tumor suppressors in human cancers. In gastric cancer (GC), miRNAs play a dual role of either promoting or inhibiting cancer invasion and metastasis. In addition, some miRNAs are involved in only the invasion or metastasis, while other miRNAs have multiple functions and participate in invasion, migration and metastasis. In this review, we will discuss the role of miRNAs in the invasion and metastasis of GC.
microRNAs (miRNAs) 是基本的基因调控因子，可在肿瘤发展过程中控制细胞增殖、分化和凋亡。这些分子在人类癌症中可以作为癌基因或肿瘤抑制因子发挥作用。在胃癌 (GC) 中，miRNAs 发挥促进或抑制癌症侵袭和转移的双重作用。此外，一些 miRNAs 仅参与侵袭或转移，而其他 miRNAs 具有多种功能并参与侵袭、迁移和转移。在这篇综述中，我们将讨论 miRNAs 在 GC 侵袭和转移中的作用。
