Chao Guanqun, Chen Xinli, Zhang Shuo
Department of Family Medicine, Sir Run Run Shaw Hospital, Zhejiang University, China.
Department of Gastroenterology, The First Affiliated Hospital, Zhejiang Chinese Medical University, China.
J Cancer. 2021 Jan 21;12(6):1838-1845. doi: 10.7150/jca.46392. eCollection 2021.
Retrospective analysis was used to determine the population diagnosed with EGC, and HP infection was used as the cut-off point to further evaluate the correlation between (HP) infection and tumor biological characteristics of early gastric cancer (EGC). All cases were collected from patients diagnosed with EGC through endoscopic surgery or surgical procedures from January 2009 to October 2018. General information, tumor site, tumor pathology, HER2 immunohistochemical results, and degree of HP infection were collected for retrospective analysis. A total of 111 cases were collected in this study. Among the HP negative group, there were statistically significant differences in tumor sites between the uninfected group and the previously infected group (<0.05).There were significant differences in monocyte infiltration and neutrophil infiltration between the positive and negative groups (<0.05).The differentiated adenocarcinoma in the positive group was significantly lower than that in the negative group. The incidence rate of Mixed type cancer was significantly higher than that in the positive group (<0.01). In the positive group of HP, there was a statistically significant difference in HER2 between the unsterilized group and the previously sterilized group (<0.05).There was a statistically significant difference in HER2 between the HP positive group and the HP negative group (<0.01). HP infection was significantly correlated with HER2 index and presented a positive correlation (=0.014). HP infection is related to the tumor site and mucosal inflammatory infiltration of EGC. The malignant degree of EGC complicated with HP infection is higher, and most of them are mixed type. The degree of HP infection was positively correlated with the degree of invasion and malignancy of ECG. Furthermore, the tumor indicator HER2 is closely related to HP infection, and the detection of HP combined with HER2 is of great significance in the discovery of EGC and the evaluation of its malignancy.
采用回顾性分析确定诊断为早期胃癌（EGC）的人群，并以幽门螺杆菌（HP）感染为分界点，进一步评估HP感染与早期胃癌肿瘤生物学特征之间的相关性。所有病例均收集自2009年1月至2018年10月期间经内镜手术或外科手术诊断为EGC的患者。收集一般信息、肿瘤部位、肿瘤病理、HER2免疫组化结果以及HP感染程度进行回顾性分析。本研究共收集111例病例。在HP阴性组中，未感染组与既往感染组的肿瘤部位存在统计学差异（<0.05）。阳性组和阴性组之间的单核细胞浸润和中性粒细胞浸润存在显著差异（<0.05）。阳性组的分化腺癌明显低于阴性组。混合型癌的发病率明显高于阳性组（<0.01）。在HP阳性组中，未除菌组与既往除菌组之间的HER2存在统计学差异（<0.05）。HP阳性组与HP阴性组之间的HER2存在统计学差异（<0.01）。HP感染与HER2指数显著相关且呈正相关（=0.014）。HP感染与EGC的肿瘤部位和黏膜炎症浸润有关。合并HP感染的EGC恶性程度较高，且大多为混合型。HP感染程度与EGC的侵袭和恶性程度呈正相关。此外，肿瘤指标HER2与HP感染密切相关，联合检测HP与HER2对EGC的发现及其恶性程度评估具有重要意义。
