Department of Endocrinology, Long Hua Hospital Affiliated to Shanghai University of Traditional Chinese Medicine, Shanghai,China.
Front Biosci (Landmark Ed). 2013 Jun 1;18(3):1080-7. doi: 10.2741/4164.
The variety of clinical presentations of eye changes in patients with Graves' disease (GD) suggests that complex interactions between genetic, environmental, endogenous and local factors influence the severity of Graves' ophthalmopathy (GO). It is thought that the development of GO might be influenced by genetic factors and environmental factors, such as cigarette smoking. At present, however, the role of genetic factors in the development of GO is not known. On the basis of studies with candidate genes and other genetic approaches, several susceptibility loci in GO have been proposed, including immunological genes, human leukocyte antigen (HLA), cytotoxic T-lymphocyte antigen-4 (CTLA-4), regulatory T-cell genes and thyroid-specific genes. This review gives a brief overview of the current range of major susceptibility genes found for GD.
Graves 病（GD）患者眼部变化的临床表现多种多样，这表明遗传、环境、内源性和局部因素之间的复杂相互作用影响 Graves 眼病（GO）的严重程度。人们认为 GO 的发生可能受到遗传因素和环境因素的影响，如吸烟。然而，目前尚不清楚遗传因素在 GO 发病中的作用。基于候选基因和其他遗传方法的研究，已经提出了 GO 的几个易感位点，包括免疫基因、人类白细胞抗原（HLA）、细胞毒性 T 淋巴细胞抗原-4（CTLA-4）、调节性 T 细胞基因和甲状腺特异性基因。本文简要综述了目前发现的与 GD 相关的主要易感基因。
