Eriksson J G, Forsén T, Tuomilehto J, Jaddoe V W V, Osmond C, Barker D J P
National Public Health Institute, Department of Epidemiology and Health Promotion, Helsinki, Finland.
Diabetologia. 2002 Mar;45(3):342-8. doi: 10.1007/s00125-001-0757-6.
AIMS/HYPOTHESIS: A study of 7086 men and women born in Helsinki, Finland, has shown that the development of Type II (non-insulin-dependent) diabetes mellitus is associated with low birth weight followed by accelerated gain in height and weight during childhood and with high maternal BMI but the processes which underlie these associations are largely not known.
We carried out standard oral glucose tolerance tests, and measured plasma insulin and proinsulin, serum lipid concentrations and blood pressure in 474 patients from the Helsinki cohort.
We used four indices of insulin resistance: fasting and 2-h plasma insulin, and fasting proinsulin and 32-33 split proinsulin concentrations. These were associated with small body size at birth and during childhood, rapid growth in height and low maternal BMI.
CONCLUSION/INTERPRETATION: Insulin resistance and Type II diabetes share common associations with retarded fetal growth and accelerated growth during childhood. They are dissimilar, however, in that insulin resistance is associated with thinness in childhood and low maternal BMI, while Type II diabetes is associated with high BMI in childhood and high maternal BMI.
目的/假设：一项针对出生于芬兰赫尔辛基的7086名男性和女性的研究表明，II型（非胰岛素依赖型）糖尿病的发病与低出生体重、儿童期身高和体重的加速增长以及高母体体重指数有关，但这些关联背后的机制大多尚不明确。
我们对来自赫尔辛基队列的474名患者进行了标准口服葡萄糖耐量试验，并测量了血浆胰岛素和胰岛素原、血脂浓度及血压。
我们使用了四个胰岛素抵抗指标：空腹及2小时血浆胰岛素、空腹胰岛素原及32 - 33裂解胰岛素原浓度。这些指标与出生时及儿童期的小体型、身高快速增长和低母体体重指数相关。
结论/解读：胰岛素抵抗和II型糖尿病与胎儿生长迟缓及儿童期生长加速有着共同的关联。然而，它们的不同之处在于，胰岛素抵抗与儿童期消瘦及低母体体重指数相关，而II型糖尿病与儿童期高体重指数及高母体体重指数相关。
