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口服和局部施用的皱盖乌芝（花银耳）可改善链脲佐菌素诱导的糖尿病小鼠的皮肤伤口愈合。

Orally and topically administered Sparassis crispa (Hanabiratake) improved healing of skin wounds in mice with streptozotocin-induced diabetes.

作者信息

Yamamoto Kyosuke, Kimura Takashi

机构信息

Research and Development Center, Unitika Ltd., Kyoto, Japan.

出版信息

Biosci Biotechnol Biochem. 2013;77(6):1303-5. doi: 10.1271/bbb.121016. Epub 2013 Jun 7.

DOI:10.1271/bbb.121016
PMID:23748764
Abstract

Sparassis crispa (SC) contains significant concentrations of β-glucan, which can accelerate wound healing, but the dose dependence for oral administration and the effects of topical administration are unknown. In streptozotocin-induced diabetic mice, dietary SC promoted dose-dependent effective wound healing. Similar wound healing activity was observed when purified SC β-glucan was topically applied to wounds of diabetic mice.

摘要

皱盖乌芝（SC）含有高浓度的β-葡聚糖，其可加速伤口愈合，但口服给药的剂量依赖性以及局部给药的效果尚不清楚。在链脲佐菌素诱导的糖尿病小鼠中，饮食中的SC可促进剂量依赖性有效伤口愈合。当将纯化的SCβ-葡聚糖局部应用于糖尿病小鼠的伤口时，观察到了类似的伤口愈合活性。

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