Elkholti Youssef, Cosmidis Alain, Ardiet Jean Michel, Laffay Lisa, De Bari Berardino
Service de Radiothérapie Oncologie, Centre Hospitalier Lyon Sud, Pierre-Bénite and EA3738, Université Claude-Bernard, Lyon, France.
Tumori. 2013 Mar-Apr;99(2):e55-60. doi: 10.1177/030089161309900229.
Adenoid cystic carcinoma (ACC) is a rare epithelioid malignancy. It occurs most frequently in the salivary glands, while its localization in the nasopharynx is rare and few cases have been reported in the literature. We report the case of a 32-year-old woman presenting with ACC of the nasopharynx who was treated with surgery and adjuvant intensity-modulated radiation therapy (IMRT, total dose: 68 Gy) and concomitant chemotherapy (cisplatin 100 mg/m² on the first and 21st days of IMRT). During irradiation, the patient developed G1 dermatitis and G2 mucositis (RTOG). Clinical and instrumental reevaluation 17 months after the end of radiotherapy did not show any signs of relapse, and she did not show any sign of local mild-severe toxicity. Adjuvant radiotherapy after standard complete surgical resection seems to be effective and well tolerated and should be strongly considered in the multidisciplinary approach to this infrequent carcinoma.
腺样囊性癌（ACC）是一种罕见的上皮样恶性肿瘤。它最常发生于唾液腺，而其在鼻咽部的定位罕见，文献中报道的病例很少。我们报告了一例32岁女性鼻咽部腺样囊性癌患者，该患者接受了手术及辅助调强放射治疗（IMRT，总剂量：68 Gy）和同步化疗（在IMRT的第1天和第21天给予顺铂100 mg/m²）。放疗期间，患者出现1级皮炎和2级黏膜炎（RTOG分级）。放疗结束17个月后的临床和影像学复查未显示任何复发迹象，且她未表现出任何局部轻至重度毒性迹象。标准的完整手术切除后辅助放疗似乎有效且耐受性良好，在这种罕见癌症的多学科治疗方法中应予以高度考虑。
