Wang C C, See L C, Hong J H, Tang S G
Department of Radiation Oncology, Chang Gung Memorial Hospital, Taipei, Taiwan.
J Otolaryngol. 1996 Dec;25(6):399-403.
Nasopharyngeal adenoid cystic carcinoma (NACC) is a rare tumour, and its mainstay treatment is different from adenoid cystic carcinoma arising from another head and neck region. In this study, we analyzed 20 cases of NACC with complete clinical information, 5 from Chang Gung Memorial Hospital and 15 from the literature review.
The time interval between first symptom and treatment ranged from 2 weeks to 8 years, with a median of 24 months. Compared with usual nasopharyngeal carcinoma, NACC has higher incidence of cranial nerve involvement (55%) and lower incidence of cervical adenopathy (15%). All patients were treated by radiotherapy and 6 patients received surgical treatment. The 5- and 10-year overall survival rates were 78% and 49.5%, respectively. Seven patients developed metastasis to lung or bone. After a minimum of 5 years' follow-up, the local control rate was 45.5% in patients receiving radiation dose > 70 Gy, and 28.6% in those receiving dose < or = 70 Gy, suggesting higher radiation dose is necessary to achieve better local control in NACC.
鼻咽腺样囊性癌（NACC）是一种罕见肿瘤，其主要治疗方法与源自其他头颈部区域的腺样囊性癌不同。在本研究中，我们分析了20例具有完整临床信息的NACC病例，其中5例来自长庚纪念医院，15例来自文献回顾。
首发症状至治疗的时间间隔为2周至8年，中位数为24个月。与普通鼻咽癌相比，NACC的脑神经受累发生率更高（55%），颈部淋巴结肿大发生率更低（15%）。所有患者均接受了放射治疗，6例患者接受了手术治疗。5年和10年总生存率分别为78%和49.5%。7例患者发生肺或骨转移。经过至少5年的随访，接受放疗剂量>70 Gy的患者局部控制率为45.5%，接受剂量≤70 Gy的患者局部控制率为28.6%，这表明在NACC中需要更高的放疗剂量以实现更好的局部控制。
