Theocharidou Eleni, Gossios Thomas D, Griva Theodora, Giouleme Olga, Douma Stella, Athyros Vasilios G, Karagiannis Asterios
2nd Propaedeutic Department of Internal Medicine, Hippokration General Hospital of Thessaloniki, Aristotle University of Thessaloniki, Thessaloniki, Greece
1st Department of Cardiology, AHEPA General Hospital of Thessaloniki, Aristotle University of Thessaloniki, Thessaloniki, Greece.
Angiology. 2014 Jul;65(6):543-50. doi: 10.1177/0003319713489876. Epub 2013 Jun 6.
Inflammation is a predictor of cardiovascular disease (CVD). Thus, inflammatory bowel diseases (IBD) may be associated with CVD. We assessed carotid intima-media thickness (cIMT; an indicator of CVD risk) in 42 patients with IBD, free of CVD or diabetes; 26 with Crohn's disease (CD) and 16 with ulcerative colitis (UC). The cIMT was significantly greater in patients with IBD compared to 42 healthy controls (0.62 ± 0.08 vs 0.52 ± 0.06 mm; P < .0005). The cIMT did not differ between patients with CD and UC or between the different disease activity and treatment groups. Factors associated with cIMT were age, body mass index, and IBD, with the latter making a greater contribution. The IBD is a predictor of cIMT, even when other CVD risk factors are considered. These findings suggest an association between early arterial wall alterations and IBD. Such an association should be proven in larger studies that should assess the incidence of CVD in patients with IBD.
炎症是心血管疾病（CVD）的一个预测指标。因此，炎症性肠病（IBD）可能与心血管疾病有关。我们评估了42例无心血管疾病或糖尿病的炎症性肠病患者的颈动脉内膜中层厚度（cIMT；心血管疾病风险指标）；其中26例患有克罗恩病（CD），16例患有溃疡性结肠炎（UC）。与42名健康对照者相比，炎症性肠病患者的cIMT显著更高（0.62±0.08 vs 0.52±0.06毫米；P<0.0005）。CD患者和UC患者之间或不同疾病活动度和治疗组之间的cIMT没有差异。与cIMT相关的因素有年龄、体重指数和炎症性肠病，其中炎症性肠病的影响更大。即使考虑其他心血管疾病风险因素，炎症性肠病仍是cIMT的一个预测指标。这些发现提示早期动脉壁改变与炎症性肠病之间存在关联。这种关联应在更大规模的研究中得到证实，这些研究应评估炎症性肠病患者心血管疾病的发病率。
