Ozdil Kamil, Caliskan Zuhal, Keles Nursen, Ozturk Oguzhan, Tekin Ahmet Selami, Kahraman Resul, Doganay Levent, Demircioglu Kenan, Yilmaz Yusuf, Caliskan Mustafa
Department of Gastroenterology, Saglık Bilimleri University Umraniye Training and Research Hospital, Istanbul, Turkey.
Department of Cardiology, Istanbul Medeniyet University Goztepe Training and Research Hospital, Istanbul, Turkey.
North Clin Istanb. 2017 May 10;4(1):4-12. doi: 10.14744/nci.2017.74508. eCollection 2017.
Inflammatory bowel diseases (IBD) consist of a number of chronic inflammatory diseases. Inflammatory process is known to be involved in all stages of atherosclerosis. Early atherosclerosis is reflected by increased levels of carotid artery intima media thickness (c-IMT) and high-sensitivity C-reactive protein (hs-CRP). Epicardial fat thickness (EFT) strongly influences both the formation and progression of atherosclerosis. Recent studies have demonstrated a relationship between c-IMT and hs-CRP levels and the risk of atherosclerosis in patients with IBD. However, no study has yet compared EFT between patients with IBD and the general healthy population. Hence, this study was designed to further evaluate whether patients with IBD have higher EFT values with increased c-IMT and hs-CRP levels compared to those in the healthy population.
A total of 110 patients with IBD and 105 healthy volunteers were enrolled into this study. EFT was evaluated by transthoracic echocardiography. c-IMT levels were measured using an ultrasound scanner with a linear probe. The plasma levels of hs-CRP were measured using a highly sensitive sandwich ELISA technique.
The hs-CRP and c-IMT levels of patients with IBD were significantly higher than those of the control group. The EFT values of patients with IBD were significantly higher than those of the control group (0.54±0.13 vs. 0.49±0.09, p=0.002).
Echocardiographic EFT measurements of patients with IBD were significantly higher than those of the normal population, which may be associated with an increased subclinical atherosclerosis risk in these patients.
炎症性肠病（IBD）由多种慢性炎症性疾病组成。已知炎症过程参与动脉粥样硬化的各个阶段。早期动脉粥样硬化表现为颈动脉内膜中层厚度（c-IMT）和高敏C反应蛋白（hs-CRP）水平升高。心外膜脂肪厚度（EFT）对动脉粥样硬化的形成和进展均有强烈影响。近期研究已证实IBD患者的c-IMT和hs-CRP水平与动脉粥样硬化风险之间存在关联。然而，尚无研究比较IBD患者与一般健康人群的EFT。因此，本研究旨在进一步评估与健康人群相比，IBD患者的EFT值是否会因c-IMT和hs-CRP水平升高而更高。
本研究共纳入110例IBD患者和105名健康志愿者。通过经胸超声心动图评估EFT。使用配备线性探头的超声扫描仪测量c-IMT水平。采用高灵敏度夹心ELISA技术测量血浆hs-CRP水平。
IBD患者的hs-CRP和c-IMT水平显著高于对照组。IBD患者的EFT值显著高于对照组（0.54±0.13 vs. 0.49±0.09，p = 0.002）。
IBD患者的超声心动图EFT测量值显著高于正常人群，这可能与这些患者亚临床动脉粥样硬化风险增加有关。
