Kothari Harit Goverdhan, Gupta Sudhir Jagdishprasad, Gaikwad Nitin Rangrao
Department of Gastroenterology, Government Medical College and Superspeciality Hospital, Nagpur, India.
Inflamm Intest Dis. 2019 May;4(1):27-34. doi: 10.1159/000499199. Epub 2019 Apr 17.
Ulcerative colitis (UC) is characterized by chronic relapsing-remitting inflammation of the gastrointestinal tract. The chronic inflammatory process may predispose to atherosclerosis. The aim of the study was to assess the carotid intima-media thickness (CIMT) and its relation to subclinical atherosclerosis and to follow up cardiovascular complications in patients with UC.
83 patients with proven UC in remission were enrolled in the study. 42 age- and sex-matched healthy controls were taken. Patients with known risk factors for atherosclerosis were excluded from the study. Baseline blood investigations along with C-reactive protein (CRP), erythrocyte sedimentation rate (ESR), and fasting lipid profile were done. CIMT was measured using B-mode Doppler imaging study.
The mean age of the UC patients was 37.06 ± 14.87 years. Left-sided colitis (45.8%) was the commonest type of presentation according to the extent of the disease. Mean CIMT (0.55 ± 0.17) was significantly higher in UC patients when compared to mean CIMT (0.46 ± 0.13) in the control group ( = 0.002). In Pearson correlation analysis, age, ESR, and CRP were positive and significantly correlated with CIMT. Multiple linear regression analysis ( = 0.18, = 0.0026) revealed that age and CRP were significant independent predictors of mean CIMT. On following up for 6 months, 4 patients with UC had complications in the form of venous thrombosis.
CIMT is a simple, noninvasive, reliable and objective auxiliary vascular parameter of structural alteration in UC patients.
溃疡性结肠炎（UC）的特征是胃肠道的慢性复发 - 缓解性炎症。慢性炎症过程可能易患动脉粥样硬化。本研究的目的是评估溃疡性结肠炎患者的颈动脉内膜中层厚度（CIMT）及其与亚临床动脉粥样硬化的关系，并随访心血管并发症。
83例经证实处于缓解期的溃疡性结肠炎患者纳入本研究。选取42例年龄和性别匹配的健康对照者。已知有动脉粥样硬化危险因素的患者被排除在研究之外。进行了包括C反应蛋白（CRP）、红细胞沉降率（ESR）和空腹血脂谱在内的基线血液检查。使用B型多普勒成像研究测量CIMT。
溃疡性结肠炎患者的平均年龄为37.06±14.87岁。根据疾病范围，左侧结肠炎（45.8%）是最常见的表现类型。与对照组的平均CIMT（0.46±0.13）相比，溃疡性结肠炎患者的平均CIMT（0.55±0.17）显著更高（P = 0.002）。在Pearson相关性分析中，年龄、ESR和CRP与CIMT呈正相关且显著相关。多元线性回归分析（R² = 0.18，P = 0.0026）显示年龄和CRP是平均CIMT的显著独立预测因素。随访6个月时，4例溃疡性结肠炎患者出现静脉血栓形成的并发症。
CIMT是溃疡性结肠炎患者结构改变的一种简单、无创、可靠且客观的辅助血管参数。
