Department of Physics, University of California at San Diego, La Jolla, California, USA.
Nat Neurosci. 2013 Jul;16(7):889-97. doi: 10.1038/nn.3426. Epub 2013 Jun 9.
What is the nature of the vascular architecture in the cortex that allows the brain to meet the energy demands of neuronal computations? We used high-throughput histology to reconstruct the complete angioarchitecture and the positions of all neuronal somata of multiple cubic millimeter regions of vibrissa primary sensory cortex in mouse. Vascular networks were derived from the reconstruction. In contrast with the standard model of cortical columns that are tightly linked with the vascular network, graph-theoretical analyses revealed that the subsurface microvasculature formed interconnected loops with a topology that was invariant to the position and boundary of columns. Furthermore, the calculated patterns of blood flow in the networks were unrelated to location of columns. Rather, blood sourced by penetrating arterioles was effectively drained by the penetrating venules to limit lateral perfusion. This analysis provides the underpinning to understand functional imaging and the effect of penetrating vessels strokes on brain viability.
大脑如何构建皮质中的血管结构来满足神经元计算的能量需求？我们利用高通量组织学技术，在小鼠触须初级感觉皮层的多个立方毫米区域中重建了完整的血管结构和所有神经元胞体的位置。从重建中得出了血管网络。与与血管网络紧密相连的标准皮层柱模型不同，图论分析表明，亚表面微血管形成了相互连接的环路，其拓扑结构与柱的位置和边界无关。此外，网络中计算出的血流模式与柱的位置无关。相反，穿透小动脉供应的血液通过穿透小静脉有效地排出，以限制侧向灌注。这种分析为理解功能成像以及穿透血管中风对大脑活力的影响提供了基础。
