Miao Xia, Chen Yong-Bin, Xu Sheng-Long, Zhao Tao, Liu Jun-Ye, Li Yu-Rong, Wang Jin, Zhang Jie, Guo Guo-Zhen
Department of Radiation Medicine, Ministry of Education Key Laboratory of Hazard Assessment and Control in Special Operational Environment, School of Public Health, Fourth Military Medical University, No. 169, Changle West Road, Xi'an, 710032, China.
Tumour Biol. 2013 Dec;34(6):3357-61. doi: 10.1007/s13277-013-0906-9. Epub 2013 Jun 9.
Upregulation of translationally controlled tumor protein (TCTP) has been reported in a variety of malignant tumors. However, the impact of TCTP in glioma remains unclear. The objective of this study was to investigate the expression and prognostic value of TCTP in glioma patients. Western blot analysis was used to characterize the expression patterns of TCTP in 45 glioma and 22 normal brain tissues. Immunohistochemistry on a tissue microarray containing 127 cases of glioma was performed to analyze the association between TCTP expression and clinicopathological features. Compared with normal brain tissues, TCTP expression was significantly higher in glioma tissues (p <0.001). In addition, high TCTP expression in glioma was significantly associated with advanced pathological grade (p = 0.018). Kaplan-Meier analysis showed that patients with glioma and higher TCTP expression tend to have shorter overall survival time (p <0.001). In multivariate analysis, TCTP expression was proved to be an independent prognostic factor for patients with glioma (p <0.001). In conclusion, this study confirmed the overexpression of TCTP and its association with tumor progression in glioma. It also provided the first evidence that TCTP expression in glioma was an independent prognostic factor of patients, which might be a potential diagnostic and therapeutic target of glioma.
据报道，翻译控制肿瘤蛋白（TCTP）在多种恶性肿瘤中上调。然而，TCTP在胶质瘤中的影响仍不清楚。本研究的目的是探讨TCTP在胶质瘤患者中的表达及预后价值。采用蛋白质免疫印迹分析来表征TCTP在45例胶质瘤组织和22例正常脑组织中的表达模式。对包含127例胶质瘤的组织芯片进行免疫组织化学分析，以分析TCTP表达与临床病理特征之间的关联。与正常脑组织相比，TCTP在胶质瘤组织中的表达显著更高（p<0.001）。此外，胶质瘤中TCTP的高表达与病理分级进展显著相关（p = 0.018）。Kaplan-Meier分析表明，TCTP表达较高的胶质瘤患者总生存时间往往较短（p<0.001）。在多变量分析中，TCTP表达被证明是胶质瘤患者的独立预后因素（p<0.001）。总之，本研究证实了TCTP在胶质瘤中的过表达及其与肿瘤进展的关联。它还首次提供了证据，表明胶质瘤中TCTP表达是患者的独立预后因素，这可能是胶质瘤潜在的诊断和治疗靶点。
