鼻腔灌洗液和血浆中的细胞因子及其与囊性纤维化临床参数的相关性。
Cytokines in nasal lavages and plasma and their correlation with clinical parameters in cystic fibrosis.
机构信息
Department of Pulmonary Medicine, Erasmus MC Rotterdam, 's-Gravendijkwal 230, 3015 CE Rotterdam, The Netherlands.
出版信息
J Cyst Fibros. 2013 Dec;12(6):623-9. doi: 10.1016/j.jcf.2013.05.002. Epub 2013 Jun 14.
BACKGROUND
Because persistent inflammation plays a dominant role in cystic fibrosis (CF), we assessed systemic and local upper airway responses during and after pulmonary exacerbation.
METHODS
We followed a cohort of Pseudomonas aeruginosa-infected adult CF patients (n=16) over time in pulmonary exacerbation and in stable disease. Interleukin (IL)-1β, IL-2, IL-4, IL-5, IL-6, IL-8, IL-10, IL-17A, IL-22, interferon-γ and TNFα levels were measured in sputum, nasal lavages and plasma.
RESULTS
In CF patients IL-6 and IL-10 levels in nasal lavages were significantly increased in exacerbation compared with stable disease. Systemic IL-6 significantly correlated with CRP levels and FEV1 (%predicted), independently of disease status. Systemic IL-10 also correlated significantly with CRP and FEV1 (%predicted), but only in exacerbation. Other cytokines tested did not discriminate between exacerbation and stable disease.
CONCLUSIONS
Determination of IL-6 and IL-10 in nasal lavages may provide a minimally invasive tool in the assessment of an exacerbation in CF.
背景
由于持续性炎症在囊性纤维化（CF）中起主导作用，我们评估了肺部恶化期间和之后全身和局部上呼吸道的反应。
方法
我们对一组铜绿假单胞菌感染的成年 CF 患者（n=16）进行了随访，观察其在肺部恶化和稳定期的情况。在痰、鼻灌洗液和血浆中测量白细胞介素（IL）-1β、IL-2、IL-4、IL-5、IL-6、IL-8、IL-10、IL-17A、IL-22、干扰素-γ和 TNFα水平。
结果
在 CF 患者中，鼻灌洗液中的 IL-6 和 IL-10 水平在恶化期明显高于稳定期。全身 IL-6 与 CRP 水平和 FEV1（%预测值）显著相关，与疾病状态无关。全身 IL-10 也与 CRP 和 FEV1（%预测值）显著相关，但仅在恶化期。其他测试的细胞因子不能区分恶化期和稳定期。
结论
鼻灌洗液中 IL-6 和 IL-10 的测定可能为 CF 恶化的评估提供一种微创工具。
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