Kashyap S, Schulze K F, Forsyth M, Dell R B, Ramakrishnan R, Heird W C
Department of Pediatrics, Columbia University College of Physicians and Surgeons, New York, NY 10032.
Am J Clin Nutr. 1990 Aug;52(2):254-62. doi: 10.1093/ajcn/52.2.254.
Growth, nutrient retention, and metabolic response of low-birth-weight infants fed human milk provided by their mother; this milk supplemented with bovine milk protein, calcium, phosphorus, and sodium; or pasteurized term human milk with the same supplement were monitored from the time desired intake was tolerated until weight reached 2200 g. The supplement resulted in greater rates of weight gain (20.5 +/- 2.3 vs 16.4 +/- 2.2 g.kg-1.d-1) and nitrogen retention (353 +/- 76 vs 270 +/- 53 mg.kg-1.d-1), increase in plasma transthyretin (TTR) concentration (7 +/- 16 vs -3 +/- 9 mg.L-1.wk-1), a higher mean plasma albumin concentration (34 +/- 3 vs 32 +/- 4 g/L), and a higher plasma TTR concentration at discharge (100 +/- 22 vs 75 +/- 24 mg/L). All these variables correlated significantly with total nitrogen intake, suggesting that the differences are attributable to the protein content of the supplement. The supplement also resulted in greater rates of calcium and phosphorus accretion but the plasma alkaline phosphatase activity of the supplemented vs the unsupplemented groups did not differ.
从他们能够耐受期望摄入量开始，直至体重达到2200克，监测这些低出生体重儿食用其母亲提供的母乳、添加了牛乳蛋白、钙、磷和钠的母乳或添加了相同补充剂的巴氏杀菌足月儿母乳后的生长情况、营养物质保留情况和代谢反应。补充剂使体重增加速率更高（20.5±2.3对16.4±2.2克·千克⁻¹·天⁻¹）、氮保留增加（353±76对270±53毫克·千克⁻¹·天⁻¹）、血浆转甲状腺素蛋白（TTR）浓度升高（7±16对−3±9毫克·升⁻¹·周⁻¹）、平均血浆白蛋白浓度更高（34±3对32±4克/升）以及出院时血浆TTR浓度更高（100±22对75±24毫克/升）。所有这些变量均与总氮摄入量显著相关，这表明差异归因于补充剂的蛋白质含量。补充剂还使钙和磷的蓄积速率更高，但补充组与未补充组的血浆碱性磷酸酶活性并无差异。
