Lewis C J, McDowell M A, Sempos C T, Lewis K C, Yetley E A
Food and Drug Administration, HFF-265, Washington, DC 20204.
Am J Clin Nutr. 1990 Aug;52(2):353-60. doi: 10.1093/ajcn/52.2.353.
The association between age and serum vitamin A concentrations in children was examined by using total serum vitamin A values from the second National Health and Nutrition Examination Survey (NHANES II) and serum retinol values for Mexican Americans from the Hispanic HANES. Analyses included multivariate strategies to identify confounders of serum vitamin A. After the effect of the use of vitamin-mineral supplements on total serum vitamin A values was controlled for, the data indicated that younger children (aged 4-5 y) have lower serum vitamin A concentrations than do older children (aged 9-11 y) regardless of whether the measure was total serum vitamin A or serum retinol. This relationship was systematic across the distribution of values and suggested that the difference may be due to normal physiological events. A different interpretive criterion may be needed for younger and older children when serum vitamin A is used to indicate vitamin A status.
利用第二次全国健康与营养检查调查（NHANES II）中的血清总维生素A值以及西班牙裔美国人营养与健康检查调查（Hispanic HANES）中墨西哥裔美国人的血清视黄醇值，对儿童年龄与血清维生素A浓度之间的关联进行了研究。分析采用多变量策略来识别血清维生素A的混杂因素。在控制了使用维生素 - 矿物质补充剂对血清总维生素A值的影响后，数据表明，无论测量指标是血清总维生素A还是血清视黄醇，年幼儿童（4 - 5岁）的血清维生素A浓度均低于年长儿童（9 - 11岁）。这种关系在整个数值分布中是系统性的，提示这种差异可能是由于正常的生理事件所致。当使用血清维生素A来指示维生素A状态时，年幼儿童和年长儿童可能需要不同的解释标准。
