Coordenação de Pesquisa Clínica e Incorporação Tecnológica, Coordenação Geral Tecnico-Científica, INCA - Instituto Nacional de Câncer, André Cavalcanti st, 37 - 5º andar - Anexo - Centro, 20231-050, Rio de Janeiro, RJ, Brazil.
Curr Oncol Rep. 2013 Aug;15(4):287-95. doi: 10.1007/s11912-013-0322-8.
The adolescent and young adult (AYA) is defined as a patient of 15 to 39 years of age at initial cancer diagnosis, and this group has particular medical needs and age-related issues. Excluding violent deaths, cancer is the leading cause of death among the AYA population. Lymphomas, melanoma, testicular cancer, female genital tract malignancies, thyroid cancer, bone and soft tissue sarcomas, leukemias, central nervous system tumors, breast cancer, and nongonadal germ cell tumors account for 95 % of the cancers in this group. Among those, the epithelial cancer of AYA comprehends the minimum amount and its incidence rates tend to increase with age. This review presents information about epidemiology, biologic peculiarities, as well as standard treatment strategies for epithelial cancers in AYA.
青少年和年轻成人（AYA）定义为在初次癌症诊断时年龄为 15 至 39 岁的患者，该群体具有特殊的医疗需求和与年龄相关的问题。排除暴力死亡，癌症是 AYA 人群的主要死因。淋巴瘤、黑色素瘤、睾丸癌、女性生殖道恶性肿瘤、甲状腺癌、骨和软组织肉瘤、白血病、中枢神经系统肿瘤、乳腺癌和非生殖细胞生殖细胞瘤占该组癌症的 95%。其中，AYA 的上皮癌占比最小，其发病率随着年龄的增长而增加。本综述介绍了 AYA 上皮癌的流行病学、生物学特征以及标准治疗策略的相关信息。
