Department of Cardiology, Adana Numune Training and Research Hospital, Adana, Turkey.
Diab Vasc Dis Res. 2013 Nov;10(6):546-9. doi: 10.1177/1479164113491125. Epub 2013 Jun 10.
We aimed to evaluate the association between serum vitamin D status and elastic properties of aorta in patients with diabetes mellitus (DM). We studied 136 patients with newly diagnosed DM (mean age: 62.9 ± 10.6 years). Serum 25-hydroxyvitamin D was measured using a direct competitive chemiluminescent immunoassay. Aortic distensibility was calculated from the echocardiographically derived ascending aorta diameters and haemodynamic pressure measurements. Left ventricle mass index (LVMI) was determined according to the Devereux formula. Multiple linear regression analysis showed that vitamin D level is independently associated with LVMI (β = -0.259, p = 0.001), aortic distensibility (β = 0.369, p < 0.001), high-sensitive C-reactive protein (hs-CRP) (β = -0.220, p = 0.002) and body mass index (β = -0.167, p = 0.015) in patients with DM. In diabetic patients, serum 25-hydroxyvitamin D level is independently associated with aortic distensibility. Vitamin D may play a role on pathogenesis of impaired elastic properties of aorta in type 2 DM.
我们旨在评估血清维生素 D 状态与糖尿病患者（DM）主动脉弹性之间的关系。我们研究了 136 名新诊断为 DM 的患者（平均年龄：62.9 ± 10.6 岁）。使用直接竞争化学发光免疫测定法测量血清 25-羟维生素 D。通过超声心动图获得的升主动脉直径和血流动力学压力测量来计算主动脉顺应性。根据 Devereux 公式确定左心室质量指数（LVMI）。多元线性回归分析表明，维生素 D 水平与 LVMI（β=-0.259，p=0.001）、主动脉顺应性（β=0.369，p<0.001）、高敏 C 反应蛋白（hs-CRP）（β=-0.220，p=0.002）和体质量指数（β=-0.167，p=0.015）独立相关。在糖尿病患者中，血清 25-羟维生素 D 水平与主动脉顺应性独立相关。维生素 D 可能在 2 型糖尿病患者主动脉弹性受损的发病机制中发挥作用。
