Gnesutta Nerina, Nardini Marco, Mantovani Roberto
Dipartimento di Bioscienze; Università degli Studi di Milano; Milano, Italy.
Transcription. 2013 May-Jun;4(3):114-9. doi: 10.4161/trns.25002. Epub 2013 May 16.
Core histones are the building block of chromatin and among the most highly conserved proteins in eukaryotes. The related "deviant" histones share the histone-fold domain, and serve various roles in DNA metabolism. We provide here a structural and functional outlook of H2A/H2B-like deviant histones in transcription, replication and remodeling.
核心组蛋白是染色质的组成部分,也是真核生物中保守性最高的蛋白质之一。相关的“异常”组蛋白共享组蛋白折叠结构域,并在DNA代谢中发挥多种作用。我们在此提供了类H2A/H2B异常组蛋白在转录、复制和重塑过程中的结构与功能概述。