Mao Yinhe, Chen Changbin
Key Laboratory of Molecular Virology and Immunology, Unit of Pathogenic Fungal Infection and Host Immunity, Institut Pasteur of Shanghai, Chinese Academy of Sciences, Shanghai, China.
University of Chinese Academy of Sciences, Beijing, China.
Front Microbiol. 2019 Jul 17;10:1645. doi: 10.3389/fmicb.2019.01645. eCollection 2019.
The CCAAT box-harboring proteins represent a family of heterotrimeric transcription factors which is highly conserved in eukaryotes. In fungi, one of the particularly important homologs of this family is the Hap complex that separates the DNA-binding domain from the activation domain and imposes essential impacts on regulation of a wide range of cellular functions. So far, a comprehensive summary of this complex has been described in filamentous fungi but not in the yeast. In this review, we summarize a number of studies related to the structure and assembly mode of the Hap complex in a list of representative yeasts. Furthermore, we emphasize recent advances in understanding the regulatory functions of this complex, with a special focus on its role in regulating respiration, production of reactive oxygen species (ROS) and iron homeostasis.
含有CCAAT框的蛋白代表了一类异源三聚体转录因子家族，在真核生物中高度保守。在真菌中，该家族特别重要的一个同源物是Hap复合体，它将DNA结合结构域与激活结构域分开，并对广泛的细胞功能调节产生重要影响。到目前为止，关于这个复合体的全面综述已在丝状真菌中有描述，但在酵母中尚未见报道。在这篇综述中，我们总结了一系列与代表性酵母中Hap复合体的结构和组装模式相关的研究。此外，我们强调了在理解这个复合体调节功能方面的最新进展，特别关注其在调节呼吸、活性氧（ROS）产生和铁稳态中的作用。
