Bettany J A, Fish D R, Mendel F C
Royal Orthopaedic National Hospital, Stanmore, Middlesex, England.
Arch Phys Med Rehabil. 1990 Aug;71(9):677-81.
High-voltage pulsed direct current (HVPC) has been shown to retard edema formation after impact injury in frogs, but the effectiveness of HVPC in reducing edema after other forms of trauma has not yet been established. The purpose of our study was to determine the effect of HVPC after simulated sprains. Hind limbs of 20 anesthetized frogs were injured by hyperflexing ankles to 90 degrees. Four 30-minute treatments were administered at 1.5-hour intervals. One limb of each subject was randomly selected to receive cathodal 120-Hz HVPC at voltages 10% lower than those needed to evoke muscle contraction. Limb volumes were measured by water displacement. ANOVA with repeated measures, Newman-Keuls post hoc tests, and selected t-tests were used to determine significance of limb volume changes. HVPC retarded edema formation. HVPC was so effective (p less than .0001) that significant differences between treated and untreated limb volumes were evident after the first treatment (p less than .01), and these differences remained throughout a 17-hour posttreatment period.
高压脉冲直流电（HVPC）已被证明可延缓青蛙受到撞击损伤后的水肿形成，但HVPC在减轻其他形式创伤后水肿方面的有效性尚未得到证实。我们研究的目的是确定HVPC在模拟扭伤后的效果。将20只麻醉青蛙的后肢通过将脚踝过度弯曲至90度来造成损伤。每隔1.5小时进行4次30分钟的治疗。每个实验对象的一条肢体被随机选择接受阴极120赫兹的HVPC，其电压比诱发肌肉收缩所需的电压低10%。通过排水法测量肢体体积。采用重复测量方差分析、纽曼-基尔斯事后检验和选定的t检验来确定肢体体积变化的显著性。HVPC延缓了水肿的形成。HVPC非常有效（p小于0.0001），以至于在第一次治疗后，治疗肢体和未治疗肢体的体积之间就出现了显著差异（p小于0.01），并且在治疗后的17小时内这些差异一直存在。
