Dolan Michael G, Graves Paul, Nakazawa Chika, Delano Teresa, Hutson Alan, Mendel Frank C
* Canisius College, Buffalo, NY.
J Athl Train. 2005 Jun;40(2):111-115.
Context: Ibuprofen is widely used to manage pain and inflammation after orthopaedic trauma, but its effect on acute swelling has not been investigated. Cathodal high-voltage pulsed current (CHVPC) at 120 pulses per second and 90% of visible motor threshold is known to curb edema formation after blunt trauma to the hind limbs of rats.Objective: To examine the effects of ibuprofen, continuous CHVPC, and simultaneous ibuprofen and CHVPC on acute edema formation after blunt trauma to the hind limbs of rats.Design: Randomized, parallel-group, repeated-measures design.Setting: Laboratory animal facility.Participants: A total of 21 3-month-old Zucker Lean rats (mass = 288 +/- 55 g) were studied.Intervention(s): We assessed the effects of ibuprofen, continuous CHVPC, and simultaneous ibuprofen and CHVPC on acute edema formation after blunt trauma to the hind limbs of rats.Main Outcome Measure(s): Limb volumes were measured immediately before and after trauma and every 30 minutes over the 4 hours of the experiment.Results: Volumes of treated limbs of all 3 experimental groups were smaller (P < .05) than those of untreated limbs, but no treatment was more effective than another.Conclusions: Ibuprofen, CHVPC, and simultaneous ibuprofen and CHVPC effectively curbed edema after blunt injury by roughly 50% relative to untreated but similarly injured control limbs of rats.
布洛芬广泛用于处理骨科创伤后的疼痛和炎症，但其对急性肿胀的影响尚未得到研究。已知每秒120次脉冲且为可见运动阈值90%的阴极高压脉冲电流（CHVPC）可抑制大鼠后肢钝性创伤后的水肿形成。
研究布洛芬、持续CHVPC以及布洛芬与CHVPC联合使用对大鼠后肢钝性创伤后急性水肿形成的影响。
随机、平行组、重复测量设计。
实验动物设施。
共研究了21只3个月大的Zucker瘦型大鼠（体重 = 288 ± 55 g）。
我们评估了布洛芬、持续CHVPC以及布洛芬与CHVPC联合使用对大鼠后肢钝性创伤后急性水肿形成的影响。
在创伤前后以及实验的4小时内每30分钟测量一次肢体体积。
所有3个实验组的治疗肢体体积均小于未治疗肢体（P < 0.05），但没有一种治疗方法比另一种更有效。
相对于未治疗但同样受伤的大鼠对照肢体，布洛芬、CHVPC以及布洛芬与CHVPC联合使用可有效抑制钝性损伤后的水肿，抑制幅度约为50%。
